Projects
Can antiepileptogenic treatments slow down the progression of Alzheimer's disease? University of Antwerp
Introducing smart polymers in the field of corneal endothelial tissue engineering: solving a blinding disease University of Antwerp
Understanding intra-tumor heterogeneity in glioblastoma in space and in time. KU Leuven
Intra-tumor heterogeneity is the main obstacle to effective cancer treatment and personalized medicine. The mechanistic underpinnings of intra-tumor heterogeneity in progression and therapeutic resistance are however largely unknown. Single-cell RNA-sequencing (scRNA-seq) has revealed significant inter- and intra-tumoral molecular heterogeneity in Glioblastoma (GBM), an aggressive brain tumor that is obstinate to most therapies. However, this ...
Allele-specific silencing of mutant KCNQ2 as a targeted treatment for KCNQ2 encephalopathy: an in vitro proof of concept study. University of Antwerp
Activating the neuregulin-1/ErbB4 pathway for treatment of heart failure. University of Antwerp
Aß, Tau and neuronal death in a novel humanized mouse model for Alzheimer Disease KU Leuven
The relationship between Amyloid ɴ(Aɴpeptide, Tau, and neuronal cell loss is a central problem in the study of Alzheimer’s disease (AD). However, cell culture or animal models do not reproduce well the cell death phenotype that is crucial to analyze this relation. As it remains unclear to what extent rodent or other species can fully reproduce the AD phenotype, such study is performed ideally in human cells. In the current project, we take ...