Projects

Despite modern personalized immunosuppressive regimens, allogeneic rejection remains the main cause of graft failure and graft survival has not significantly changed over the last decades. The current canonical worldview mainly relates rejection to donor-recipient HLA mismatch and (donor-specific) HLA-antibodies (DSA). Accordingly, the widely used international Banff classification dichotomizes rejection to T-cell ...

After kidney transplantation, patients are at risk of graft failure. Graft failure is often the result of a combination of various histological disease processes, such as antibody-mediated rejection, T-cell mediated rejection, glomerular disease and polyomavirus nephropathy. Current diagnostic classification systems (including the Banff classification) do not take into account prognostic information, though ...

Rejection of kidney transplants is a complex interplay of the genetic disparity between donors and recipients and activation of the immune system of the host by these mismatched antigens. In recent years, we and others have demonstrated the role of innate allorecognition, as exemplified by natural killer cell–mediated microvascular inflammation through missing self, and by monocyte-driven allorecognition. The international Banff ...

Despite the development of potent immunosuppressive therapy, rejection remains the most frequent cause of premature graft loss after kidney transplantation, highlighting the need to better understand the underlying mechanisms. The current paradigm of kidney transplant rejection distinguishes between T-cell mediated rejection (TCMR), referring to tubulointerstitial inflammation caused by alloreactive T lymphocytes, and ...

Kidney transplant rejection is a complex interplay of the genetic disparity between donors and recipients and the immune system of the host by these mismatched antigens. We and others have demonstrated the role of innate allorecognition, as exemplified by NK cell–mediated microvascular inflammation through missing self, and by monocyte-driven allorecognition. The Banff classification for kidney transplant rejection does not represent the full ...

Kidney transplantation is the preferred treatment for end stage renal disease. However, allo-reactive immune response against the donor kidney can lead to rejections and increased risk of graft dysfunction or loss. Depending on the immune mechanism involved, rejections can be classified as antibody-mediated rejection (ABMR), T cell-mediated rejection (TCMR), and mixed rejections. Next to rejection, also signs of ...