Projects

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of pulmonary embolism (PE), characterized by fibro-thrombotic material obliterating large pulmonary arteries. The incidence of CTEPH after PE is about 3%, with patients presenting at advanced stages with compromised haemodynamic profile and limited exercise capacity. Treatment is complex, involving surgery, angioplasty and drugs. There is an urgent need to i) ...

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of pulmonary embolism (PE). However, the absence of specific symptoms prevents or delays its diagnosis. Treatment is complex, involving high-risk surgery (pulmonary endarterectomy; PEA), angioplasty and drugs, and is not always efficient. There is a crucial need to understand why a subset of patients develop CTEPH after acute PE and to implement therapeutic ...

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of pulmonary embolism (PE), characterized by fibrothrombotic material obliterating large pulmonary arteries. The disease is underdiagnosed and the treatment (high-risk surgery, angioplasty and drugs) is complex. There is an unmet need to identify patients at risk developing CTEPH after acute PE. Both pulmonary arterial smooth muscle and endothelial cells (PAECs) ...

Pulmonary arterial hypertension (PAH) is caused by a pathological increase in pulmonary vascular resistance (PVR) and ultimately leads to right ventricular (RV) failure. On modern therapy, there is still 15% mortality within 1 year and median survival remains limited to 5-6 years, with insufficient functional improvement in many survivors. Bilateral lung transplantation (bLTx) remains the only curative ...

The degree of RV dysfunction is an important determinant of mortality and exercise capacity in cardiopulmonary disease. Unfortunately, detection of RV dysfunction is most often delayed, when impairment is severe. Early detection could have important clinical implications for the management of these patients. Furthermore, demonstration of RV dysfunction during exercise might help explain symptoms such as exertional dyspnea or exercise ...

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of pulmonary embolism (PE), characterized by fibro-thrombotic material obliterating large pulmonary arteries. The incidence of CTEPH after PE is about 3%, with patients presenting at advanced stages with compromised haemodynamic profile and limited exercise capacity. Treatment is complex, involving surgery, angioplasty and drugs. There is an urgent ...

The cardiovascular system contains two separate circuits, the pulmonary and the systemic circulation, which is paralleled in cardiac anatomy by the division of the heart into a right and a left side. The right heart pumps the deoxygenated blood it receives from the systemic veins into the pulmonary circulation while the left heart then propels the oxygenated blood back into the systemic circulation. Historically, evaluation or ...