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From Biofilm Formation to Clinical Infection: Novel Insights into the Prevention and Management of Vascular Graft Infections KU Leuven

Hozan Mufty
Vascular Surgery, Microbial and Plant Genetics (CMPG)

The main work package of the research will be the investigation and time dependent visualisation of the biofilm forming process at different locations on vascular grafts. In vitro research will be the initial focus. Both local inoculation on a static model and on a flow model will be used. Different analytic methods such as FISH and confocal microscopy will be applied. Both mono- and ...

Persistence in Streptococcus pneumoniae infections: elucidation of the importance of persister cells in chronic and recurrent infections University of Antwerp

Paul Cos
Katholieke Universiteit Leuven, Catholic University of Louvain, Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
Streptococcus pneumoniae is an important human pathogen, as it is one of the most common causes of community-acquired pneumonia and otitis media. Several issues arise when battling these infections. First, replacement of vaccine-serotypes by new ones has been observed. Second, antibiotic resistance is an emerging problem. Also, antibiotic persistence is considered an important, yet underexposed phenomenon. Persister cells are a subpopulation of ...

Development and validation of a bona fide iPSC derived human neuronal infection model to evaluate antivirals targeted against neurotropic viral infections. University of Antwerp

Peter Delputte
Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID), Laboratory for Experimental Hematology (LEH), Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
Neurotropic viral infections continue to cause major disease and economic burden. Such infections are most commonly caused by herpesviruses, arboviruses and enteroviruses, often leading to severe neurological damage with poor clinical outcomes. The search for interventions to prevent and/or treat these infections is however challenging. The main reason for this is the nature of the target cells, neurons, which are chiefly non-renewable and ...

Investigating virus-induced morbidity in filarial infections (VILARIA). (VILARIa) University of Antwerp

Joseph Nelson Siewe Fodjo
Global Health Institute (GHI)
Filarial parasites cause over 200 million infections globally. Filarial morbidity was presumably limited to the skin, eyes, and lymphatic vessels. However, my research generated evidence that Onchocerca volvulus infection also induces neurological disease including Onchocerciasis-Associated Epilepsy (OAE). However, the causal mechanisms for neurological symptoms linked to O. volvulus infection are still unknown. Recently my research group ...

Resistance, tolerance and avoidance as strategies against multiple infections in Mastomys natalensis: a role of personality? University of Antwerp

Herwig Leirs
University of Insubria, Evolutionary ecology group (EVECO)
Animals have evolved three strategies to prevent and survive infections: i) avoiding the encounter with infectious agents (i.e., avoidance), ii) limiting parasite proliferation (i.e., resistance), iii) reducing the damage caused by the infection (i.e., tolerance). However, these strategies induce costs for hosts resulting in a trade-off between defence mechanisms and fitness traits (e.g., growth, reproduction). These trade offs may differ ...

Targeting Immunothrombosis in Staphylococcus aureus infections and endocarditis KU Leuven

Peter Verhamme
Centre for Molecular and Vascular Biology
Staphylococcus aureus (S. aureus) is the deadliest infectious agent, and its increasing antibiotic resistance has urged the WHO to proclaim it as a top research priority. In contrast to other infections, infective endocarditis (IE) remains highly fatal despite advances in clinical care. With an increasing incidence and unacceptably high mortality, there is an urgent need to understand how IE differs from other infections, and how the ...

Analysis of trypanosomosis-associated destruction of immunological memory during T. evansi infections (FWOAL894) Vrije Universiteit Brussel

Stefan Magez
Department of Bio-engineering Sciences
Trypanosomes cause disease in a wide host range, including humans, livestock and game animals. Historically, trypanosomosis has been an "African" disease, but parasites that no longer need tseste fly transmission have now found their way into South America, Asia and Europe. T. evansi is in this respect the most successful and widespread trypanosome, causing a world-wide infection issue. For some time now, it is known that T. evansi infections ...