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How the recognition of responsibility, remorse and apologies can make a difference in judge's decision-making in sentencing and the execution of sentences? University of Antwerp

Joëlle Rozie
Law Enforcement
In order to make individualization possible, the Belgian criminal judge enjoys great discretionary power in sentencing and the execution of sentences. Recently, increasing importance has been attached to the person of the offender and his personal improvement. However, a great lack of clarity remains about how and in which way the judge gives substance to this in practice. The combination of great judicial freedom and a lack of knowledge about ...

CONVICT: sentencing Cancer cells to death through ONcolytic Virotherapy and modulation of the Immune Checkpoint TIGIT (FWOSB112) Vrije Universiteit Brussel

Nick Devoogdt, Katty Zeven
Molecular Imaging and Therapy, Supporting clinical sciences
Immunotherapy to combat cancer has become well-established alongside conventional cancer therapies in the last decade. Notably, classical immune checkpoint inhibition (ICI) for PD-1/PD-L1 and CTLA-4 using monoclonal antibodies (mAbs) has achieved significant clinical impact in various cancers. Despite the promising clinical results, a large group of patients do not benefit from this therapy. Therefore, novel immune checkpoints (e.g. LAG-3 and ...

‘Back-end sentencing’. Exploring decision-making processes and practices of recall to prison (FWOAL713) Vrije Universiteit Brussel

Kristel Beyens
FORMER_Crime & Society, Criminology
Internationally, the number of offenders being recalled to prison during their license period has increased dramatically. In England and Wales for instance, the number of offenders being recalled to prison has augmented more than three or fourfold. For Belgium, partial figures indicate that between 42% and 46% of the conditional release orders are recalled to prison. The last decade, a growing number of scholars have focused on the possible ...

European sentencing principles for corporations. KU Leuven

Frank Verbruggen
Institute of Criminal Law, Institute for European Law
The EU is strengthening its grip on national criminal law to fight corporate crime and the punishment of corporations features prominently among its concerns. Yet its policy seems unlikely to obtain pan-European results, if sentencing rules are to remain an exclusive member state policy. Europe must therefore agree on common principles which will promote consistency in sentencing throughout Europe. Strikingly, a thorough analysis of sentencing ...

Consistency in sentencing: a dream or reality? University of Antwerp

Joëlle Rozie
Law Enforcement
It is necessary to come to a common idea about the gravity of the offence in order to make the Belgian legal criminal system less irrational. There is also a large scale of modalities of punishment. Meanwhile, there is a world of difference between judgments in similar cases. As far as the sentencing system is concerned, there is a crying need for more consistency and less irrationality. The project aims at studying this evolution and at ...

Unity of intent when sentencing: the European dimension of ne bis in idem and proportionality Ghent University

Wendy De Bondt
Department of Criminology, Criminal Law and Social Law

“Unity of intent” between different criminal acts impacts upon sentencing in that it will lead to a more lenient penalty. This lineancy seizes to exist in a European/EU context. Based upon a European/EU and comparative law analysis, the current situation will be analysed in light of the ne bis in idem and
proportionality principle.

High-Precision Mapping of HLA Gene Links to Clozapine-Induced Neutropenia via Long-Read Amplicon Sequencing with Double UMIs Ghent University

Filip Van Nieuwerburgh
Department of Pharmaceutics
The risk of developing clozapine-induced neutropenia is closely linked to the duration of drug therapy, with the majority of cases occurring within the first 18 weeks. This study explores the use of double unique molecular identifiers (UMIs) combined with high-accuracy long-read nanopore sequencing for HLA gene analysis, annotation of HLA gene variants and evaluating their associations with adverse reaction to clozapine.

Robust, sustainable and semi-automated sequencing library preparation through Mantis dispensing and PuriFY clean-up Ghent University

Jo Vandesompele
Department of Biomolecular Medicine, Department of Basic and Applied Medical Sciences, Department of Movement and Sports Sciences, Department of Bio-analysis, Department of Human Structure and Repair

Our lab develops RNA-based technologies for diagnostics and therapeutics, with a focus on cancer, liquid biopsies, and spatial transcriptomics. To improve sequencing library preparation, we seek funding for a Mantis liquid dispenser and PuriFY bead purification system. Together, they will automate low-volume pipetting and magnetic bead clean-up, reducing hands-on time, plastic waste, and variability. These tools enable robust, scalable ...

De novo mass spectrometry peptide sequencing with a transformer large language model. University of Antwerp

Wout Bittremieux
ADReM Data Lab (ADReM)
Proteomics aims to achieve a comprehensive understanding of biological systems by characterizing proteins and their modifications. A central computational challenge in mass spectrometry (MS)-based proteomics is the identification of peptides from tandem MS spectra. Conventional database search methods are limited by their dependence on existing protein sequence databases, leaving a large fraction of spectra unidentified. De novo peptide ...

Leveraging Long-Read Genome Sequencing and Neuronal Models to Unravel Inherited Peripheral Neuropathies and Identify Therapeutic Targets in α-Spectrinopathies. University of Antwerp

Jonathan Baets
Translational Neurosciences (TNW)
Neuromuscular and neurogenetic disorders are individually rare but collectively common diseases causing lifelong disabilities and healthcare burdens. This project aims to improve diagnosis and treatment. Our research focuses on inherited peripheral neuropathies (IPN), hereditary spastic paraplegia (HSP), and spinocerebellar ataxia (SCA), where cytoskeletal defects and impaired intracellular transport drive disease. Long-read whole genome ...