Publications
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COVID-19-related health utility values and changes in COVID-19 patients and the general population University of Antwerp
Purpose To summarise the diverse literature reporting the impact of COVID-19 on health utility in COVID-19 patients as well as in general populations being affected by COVID-19 control policies. Methods A literature search up to April 2023 was conducted to identify papers reporting health utility in COVID-19 patients or in COVID-19-affected general populations. We present a narrative synthesis of the health utility values/losses of the retained ...
Multimorbidity healthcare expenditure in Belgium University of Antwerp
Background The complex management of health needs in multimorbid patients, alongside limited cost data, presents challenges in developing cost-effective patient-care pathways. We estimated the costs of managing 171 dyads and 969 triads in Belgium, taking into account the influence of morbidity interactions on costs. Methods We followed a retrospective longitudinal study design, using the linked Belgian Health Interview Survey 2018 and the ...
More entities, more problems? Individual-based models for infectious disease transmission University of Antwerp
As is evident from the current COVID-19 pandemic, infectious diseases pose a significant threat to humanity. As such, the prevention and control of communicable diseases is an important topic for research. As it is not feasible to answer all questions related to this topic through empirical research, it is sometimes necessary to use mathematical models. Individual-based models explicitly track each individual in a population, and can thus ...
Longitudinal social contact data analysis University of Antwerp Hasselt University KU Leuven
Background During the COVID-19 pandemic, the CoMix study, a longitudinal behavioral survey, was designed to monitor social contacts and public awareness in multiple countries, including Belgium. As a longitudinal survey, it is vulnerable to participants'"survey fatigue", which may impact inferences. Methods A negative binomial generalized additive model for location, scale, and shape (NBI GAMLSS) was adopted to estimate the number of contacts ...
Assessing the impact of COVID-19 passes and mandates on disease transmission, vaccination intention, and uptake University of Antwerp Hasselt University KU Leuven
PurposePolicymakers have struggled to maintain SARS-CoV-2 transmission at levels that are manageable to contain the COVID-19 disease burden while enabling a maximum of societal and economic activities. One of the tools that have been used to facilitate this is the so-called "COVID-19 pass". We aimed to document current evidence on the effectiveness of COVID-19 passes, distinguishing their indirect effects by improving vaccination intention and ...
Cost-effectiveness of respiratory syncytial virus preventive interventions in children University of Antwerp
Objectives: Model-based cost-effectiveness analyses on maternal vaccine (MV) and monoclonal antibody (mAb) interventions against respiratory syncytial virus (RSV) use context-specific data and produce varied results. Through model comparison, we aim to characterize RSV cost-effectiveness models and examine drivers for their outputs.Methods: We compared 3 static and 2 dynamic models using a common input parameter set for a hypothetical birth ...
Investigating confounding in network-based test-negative design influenza vaccine effectiveness studies University of Antwerp
Background: Establishing a large study network to conduct influenza vaccine effectiveness (IVE) studies while collecting appropriate variables to account for potential bias is important; the most relevant variables should be prioritized. We explored the impact of potential confounders on IVE in the DRIVE multi-country network of sites conducting test-negative design (TND) studies.Methods: We constructed a directed acyclic graph (DAG) to map the ...
The estimated disease burden of COVID-19 in Japan from 2020 to 2021 University of Antwerp
Background: To date, it is not fully understood to what extent COVID-19 has burdened society in Japan. This study aimed to estimate the total disease burden due to COVID-19 in Japan during 2020-2021.Methods: We stratify disease burden estimates by age group and present it as absolute Quality Adjusted Life Years (QALYs) lost and QALYs lost per 100,000 persons. The total estimated value of QALYs lost consists of (1) QALYs lost brought by deaths ...
Respiratory syncytial virus prevention within reach University of Antwerp KU Leuven
Respiratory syncytial virus is the second most common cause of infant mortality and a major cause of morbidity and mortality in older adults (aged >60 years). Efforts to develop a respiratory syncytial virus vaccine or immunoprophylaxis remain highly active. 33 respiratory syncytial virus prevention candidates are in clinical development using six different approaches: recombinant vector, subunit, particle-based, live attenuated, chimeric, ...