Projects
Brain plasticity for healthy aging: enhancing motor, and cognitive functions by motor training and noninvasive brain stimulation (NIBS). Hasselt University
Opening the brain blood barrier to treat brain tumours KU Leuven
Glioblastoma, the most common form of malignant primary brain tumour in adults, is an incurable disease with a poor prognosis and an average survival rate of about 15 months under current therapies. One of the major obstacles to treatment is the blood brain barrier. Part of our body’s natural defence system, the blood brain barrier keeps disease-causing pathogens from passing into brain tissue, but it also blocks medicines that ...
Deciphering the mechanism of extracellular vesicle entry into the brain via the blood-cerebrospinal fluid barrier and possible applications as innovative brain targeting strategy. Ghent University
Peripheral blood is separated from the brain by the presence of central nervous system (CNS)
barriers. These barriers are essential for brain homeostasis, but are also responsible for the
inability of many therapeutic molecules to enter the brain. The blood-cerebrospinal fluid (CSF) CNS
barrier forms a unique interface between blood and CSF and is composed of a single layer of
cuboidal choroid ...
Modeling and visualization of multimodal brain monitoring in acute brain injury KU Leuven
The intensive care medicine department (ICU) treat patients in life threating conditions, who usually require multi-organs support. ICU combines high clinical skills, a fully dedicated patient care system and sophisticated technology. Moreover, different physiological parameters are continuously monitored. Despite that, the ICU mortality in Europe remains around 20%. Acute brain injuries (ABI) gather most of neurological injuries that occur ...
Aging and brain plasticity: alterations in brain structure, function and connectivity during motor coordination. KU Leuven
The Human Brain Project: Understanding the human brain KU Leuven
Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around ...
This grant is to support the work conducted by Patrik Verstreken on project Brain on a Chip Hands- On Training Workshops (VIB) to support hands-on "brain on a chip" trainings for researchers in the Neurodegeneration Challenge Network (NDCN) Flanders Institute for Biotechnology
Extracellular vesicle (EV) transport across the brain barriers: from mechanistic and biological insights towards strategies for delivery of therapeutics to the brain. Ghent University
Extracellular vesicles (EVs) are nanosized membrane vesicles released by a broad range of cells. We study the mechanism by which EVs cross the central nervous system (CNS) barriers using innovative EV-loading technologies and surface proteome analysis. Next, we use this knowledge to develop novel brain targeting strategies for drug delivery.
Common brain mechanisms underlying the control of imitative behaviour and mental state attribution: a transcranial brain stimulation study Ghent University
The observation of an action is associated with the activation of the corresponding
motor representation in the observer. This motor mirroring may allow us to infer
underlying goals and intentions of others on the basis of what our own goals and
intentions would be for the same action. Representing actions of the self and others
in common may usually lead to an automatic tendency to imitate the ...