A model based analysis of chrocyte response after autolgous chondrocyte implantation to repair cartilage defects in the tibiofemoral joint. KU Leuven
Local cartilage defects in the knee mostly originate from (sport) injuries. In the best-case scenario, the defect heals spontaneously with the formation of fibrous tissue which is characterized by collagen type I. This fibrous tissue has inferior biomechanical properties compared to native cartilage and is more prone to failure with the future risk of osteoarthritis. The chondrocytes’ ability of cartilage specific extracellular matrix (ECM) ...