Projects
Interaction of CMP, surface preparation, and material properties on hybrid bonding for 3D integration KU Leuven
Over the past few decades, 3D integration has developed as a field in which multiple dies are stacked and electrically connected. Traditionally, microbumps have been used as a method to increase interconnect densities, enabling the pitch to scale down to a few microns. However, further scaling is challenging, e.g. due to mechanical stability which becomes problematic at small bump diameters and the impact of Kirkendall voids on the electrical ...
Data Integration in Drug-Target Interaction Prediction for Drug Discovery and Drug Repositioning KU Leuven
Approved drugs have favorite or validated pharmacokinetic properties and toxicological profiles, and the repositioning of existing drugs for new indications can potentially avoid expensive costs associated with early-stage testing of the hit compounds. In recent years technological advances in virtual screening methodologies have allowed medicinal chemists to rapidly screen drug library for therapeutic activity against new biomolecular ...
Soil-structure interaction framework for monopiles in sand under cyclic loading KU Leuven
Recent developments in the offshore renewable energy sector have resulted in bigger wind turbines and thus an increase in the most commonly used monopile foundation’s diameter to guarantee their performance, especially under higher lateral cyclic loads due to waves and wind. Taking into account the effects of the cyclic loading especially on the long-term foundations’ capacity highlights the monopiles’ ability to control the response as well ...
Cyclic soil-structure interaction framework for the foundations of offshore renewable energy structures KU Leuven
Developing a nanocellulose-based reversible flocculant for harvesting microalgae through better understanding of the interaction between the flocculant and the microalgal cell surface KU Leuven
Microalgae are a promising new source of biomass that can be used for energy, feed, food or various high value applications. A challenge in microalgae production is the harvesting, which requires separating the microalgal cells from the liquid cultivation medium. Microalgae can be harvested by aggregating individual small cells into flocs that settle down spontaneously. Yet, this requires addition of a chemical flocculant that ends up in and ...
Towards a blueprint for successful collaborative writing and revision in higher education: the interplay of instruction, interaction and writing processes and  task complexity and their relation to text quality. KU Leuven
Bioinformatics for single-cell sequence and in situ RNA analytics to study cell niches and cell-cell interaction KU Leuven
single-cell RNA-seq procedures alone are insufficient to deliver comprehensive insight in organ cell atlases in health and disease. Indeed, as most of our organ functions are executed by the concerted action of individual cells in a spatially organized context, it is paramount to research single cells in their native spatial context. This is not only important to understand normal organ development and function, but also to investigate how ...
Development of a microfluidic device for interaction with the brain KU Leuven
The brain is one of the most important yet delicate organs in the human body. Its vital role and its inherent vulnerability are the main reasons why a sheltered environment is necessary to preserve physiological functions. A specialised structure, known as the blood-brain barrier (BBB), is in place to ensure that only the right compounds can get in contact with neural tissue. This barrier, however, is the main reason why aggressive ...