Projects
The Market Access of Complementary diagnostics Vlerick Business School
Value and Market Access of Complementary Diagnostics KU Leuven
SUMMARY
Precision medicine relies on two technologies jointly working together to deliver benefit to patients, a medicine on the one hand and a diagnostic on the other. The diagnostic’s purpose is to identify the right patient population for the medicine, and could be considered complementary to the use of the medicine. In recent years the market access of these complementary diagnostics has been scrutinized as being inadequate to ...
Genomic diagnostics beyond the sequence KU Leuven
Cytogenetic diagnostic approaches provide information on the single-chromosome level but suffer from low resolution and throughput. In contrast, next generation sequencing (NGS) based diagnostics provides single base resolution and high throughput but suffer from short reads that prevent analysis of large genomic aberrations as well as being prone to PCR-amplification bias and erasure of epigenetic information. This proposal aims to bridge ...
Preemie - revolutionary EEG-based diagnostics for premature babies. KU Leuven
The aim of this project is to finalize the software development, to validate the algorithms in the Neonatal Intensive Care Units (NICUs) and to develop a platform to view EEG data from a distance.
Improving diagnostics, treatment and care in people living with early-onset epilepsy in Rwanda Ghent University
Epilepsy is one of the most common chronic neurological disorders affecting 70 million people worldwide of whom 85% live in low- and middle income countries. The epilepsy treatment gap, which includes the diagnosis gap, amounts to 80% in sub-Saharan Africa (SSA). In 80% of people living with epilepsy in SSA, their first seizure appears before 18 years of age. Early-onset epilepsies (EOE) are important causes for childhood morbidity in the ...
Preparing for the introduction of exotic strains of the Ralstonia solanacearum species complex (i.e. of Ralstonia pseudosolanacearum and Ralstonia syzygii) – valorisation of culture collections and validation of diagnostics and methods for epidemiosurveil Research Institute for Agriculture, Fisheries and Food
The so-called RSSC soil bacteria are known to cause wilt in potato and tomato and in certain ornamental plants, for example Pelargonium and Anthurium. The identification method for 'Ralstonia solanacearum species complex' (RSSC) is not yet totally established. RSSC has four phylotypes classified into three different species: R. solanacearum (phylotype II), R. pseudosolanacearum (phylotypes I and III) and R. syzygii ...
ENERGISE: nExt-geNEration Rapid phenotypic bacterioloGy dIagnostics for low-reSource and rEmote settings Ghent University
Antimicrobial resistance (AMR) is a major global threat, particularly in low-resource settings (LRS)
like sub-Saharan Africa. Alas, diagnosing bacterial infections and preventing AMR is hampered by a
lack of feasible diagnostic tests, like blood culture diagnostics. Current methods are exceedingly
complex to implement in the settings where the crisis of AMR is already most acute. To address this,
a partnership between ...
Soft optoelectronics and ion-based circuits for diagnostics and closed-loop neuromodulation of the auditory pathway Ghent University
Understanding and modulating neural networks requires high-resolution acquisition of neural activity over time, real-time analysis, and minimally invasive stimulation methods with high specificity. Such procedures are particularly needed for treatment of sensory disfunction (e.g. hearing loss), and certain neurological diseases (e.g. epilepsy). The lack of soft, biocompatible, hybrid and smart neural interfaces hinders our capacity to study ...
Genetically-encoded cysteine and cystine biosensors for real-time monitoring and diagnostics KU Leuven
Cysteine is an essential amino acid that is required for proper cell functioning via its redox-active thiol group. Dysregulation of cysteine metabolism is implicated in diseases such as cystinosis, while insufficient cysteine supply triggers ferroptosis, a type of cell death with a promising potential in cancer therapy. Despite its seemingly well-established nature, many fundamental aspects in cysteine metabolism remain unknown due to a lack ...