Identifying a pain signature in classical Ehlers-Danlos syndrome Ghent University
Pain represents a major challenge to modern medicine, as it is often inadequately controlled by currently used analgesics. Recent studies provide evidence that the extracellular matrix (ECM) plays an important role in the development and persistence of pain. Strikingly, chronic pain is one of the most common complaints of patients suffering from genetic alterations affecting the ECM. The Ehlers-Danlos Syndromes (EDS) comprise a heterogeneous ...