Publications

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[Drug-drug interactions with risk of QT-prolongation. A epidemiological study in Belgian community pharmacies]. KU Leuven

Eline Vandael, Isabelle De Wulf, Veerle Foulon
Introduction Community pharmacists have an important role in the management of drug-drug interactions (DD). One of the interactions that can lead to serious adverse drug events, more specifically Torsade de Pointes and sudden cardiac death, are DDI with risk of CT-prolongation. Many drugs from different therapeutic classes have been linked with the risk of QT-prolongation (as listed in the QT-drug lists of CredibleMeds]. Moreover, ...

Increased incidence of forced admissions in Belgium and the Netherlands? An epidemiological approach KU Leuven

Katrien Schoevaerts, Ronny Bruffaerts, Joris Vandenberghe
An increase of compulsory admissions in Belgium and the Netherlands: an epidemiological exploration – K. Schoevaerts, R. Bruffaerts, C.L. Mulder, J. Vandenberghe –background Although compulsory admission (CA) is highly relevant to society, epidemiological data for European countries are scarce and of limited reliability and comparability. In several European countries the incidence of CA seems to be increasing.aim To estimate the incidence and ...

International epidemiological differences in acute poisonings in pediatric emergency departments Ghent University

Santiago Mintegi, Beatriz Azkunaga, Javier Prego, Nadeem Qureshi, Stuart R Dalziel, Eunate Arana-Arri, Yordana Acedo, Lorea Martinez-Indart, Arantza Urkaregi, Nerea Salmon, et al.
Background and Objective: Identifying international differences in the epidemiology of acute poisonings in children may help in improving prevention. We sought to evaluate the international epidemiological differences in acute poisonings in children presenting to emergency departments (EDs) from 8 different global regions. Methods: This was an international multicenter cross-sectional prospective study including children younger than 18 years ...

Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa; a systematic review Institute of Tropical Medicine

Temmy Sunyoto, Kristien Verdonck, Sayda El-Safi, Julien Potet, Albert Picado, Marleen Boelaert

INTRODUCTION: Cutaneous leishmaniasis (CL) is the most frequent form of leishmaniasis, with 0.7 to 1.2 million cases per year globally. However, the burden of CL is poorly documented in some regions. We carried out this review to synthesize knowledge on the epidemiological burden of CL in sub-Saharan Africa.

METHODS: We systematically searched PubMed, CABI Global health, Africa Index Medicus databases for publications on CL and its ...

Risk management of QTc-prolongation in patients receiving haloperidol: an epidemiological study in a University hospital in Belgium KU Leuven

Eline Vandael, Bert Vandenberk, Joris Vandenberghe, Isabel Spriet, Rik Willems, Veerle Foulon
BACKGROUND: Many drugs, including haloperidol, are linked with a risk of QTc-prolongation, which can lead to Torsade de Pointes and sudden cardiac death. OBJECTIVE: To investigate the prevalence of concomitant risk factors for QTc-prolongation in patients treated with haloperidol, and the use of safety measures to minimize this risk. SETTING: University Hospitals of Leuven, Belgium. Methods A retrospective epidemiological study was performed. On ...

Clinical prediction rules combining signs, symptoms and epidemiological context to distinguish influenza from influenza-like illnesses in primary care University of Antwerp

Barbara Michiels, Isabelle Thomas, Paul Van Royen, Samuel Coenen
Background During an influenza epidemic prompt diagnosis of influenza is important. This diagnosis however is still essentially based on the interpretation of symptoms and signs by general practitioners. No single symptom is specific enough to be useful in differentiating influenza from other respiratory infections. Our objective is to formulate prediction rules for the diagnosis of influenza with the best diagnostic performance, combining ...

An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis Hasselt University

Michal KICINSKI, Jaco VANGRONSVELD, Tim NAWROT
Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were ...

Longitudinal study based on a safety registry for malaria patients treated with artenimol-piperaquine in six European countries Institute of Tropical Medicine

Nicolas Vignier, Olivier Bouchaud, Andrea Angheben, Emmanuel Bottieau, Guido Calleri, Joaquin Salas-Coronas, Charlotte Martin, José Manuel Ramos, Matthieu Mechain, Christophe Rapp, et al.

BACKGROUND: European travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of endemic regions. The safety profile, especially cardiac issues, of artenimol (previously dihydroartemisinin)-piperaquine (APQ) Eurartesim® during treatment of uncomplicated imported falciparum malaria is not adequately described due to the lack of longitudinal studies in this population. The ...

Impact of retreatment with an artemisinin-based combination on malaria incidence and its potential selection of resistant strains: study protocol for a randomized controlled clinical trial Institute of Tropical Medicine

H. Muvindo Mahoko, C Nabasumba, Halidou Tinto, D'Alessandro, M.P. Grobusch, Jean-Pierre Van Geertruyden
BACKGROUND: Artemisinin-based combination therapy is currently recommended by the World Health Organization as first-line treatment of uncomplicated malaria. Recommendations were adapted in 2010 regarding rescue treatment in case of treatment failure. Instead of quinine monotherapy, it should be combined with an antibiotic with antimalarial properties; alternatively, another artemisinin-based combination therapy may be used. However, for ...

Effectiveness of yearly, register based screening for chlamydia in the Netherlands: controlled trial with randomised stepped wedge implementation Institute of Tropical Medicine

Ingrid V. F. van den Broek, Jan E. A. M. van Bergen, Elfi E H G Brouwers, Johannes S A Fennema, Hannelore M Götz, Christian J. P. A. Hoebe, Rik H Koekenbier, Mirjam Kretzschmar, Eelco A B Over, Boris V Schmid, et al.

OBJECTIVE: To evaluate the effectiveness of register based, yearly chlamydia screening.

DESIGN: Controlled trial with randomised stepped wedge implementation in three blocks.

SETTING: Three regions of the Netherlands: Amsterdam, Rotterdam, and South Limburg.

PARTICIPANTS: 317 304 women and men aged 16-29 years listed on municipal registers at start of trial.

INTERVENTION: From March 2008 to February 2011, the Chlamydia ...