Projects
Pollution in early life, mitochondrial and epigenetic effects at birth Hasselt University
Epigenetic regulation of multiple myeloma cells within the bone marrow microenvironment: identification of new potential targets Vrije Universiteit Brussel
An epigenetic DNA modification signature as a biomarker for prognosis in children with neuroblastoma Ghent University
We wish to validate a DNA methylation prognostic classifier that can differentiate between high-risk and low-risk neuroblastoma patients. To select candidate markers, MBD2-sequencing will be performed on primary tumor samples, combined with an integrative analysis of earlier research results. Using MSP, these markers will then be validated in independent patient sets and on patient bone marrow and serum samples.
The consequences of high free fatty acid concentrations in the follicular microenvironment on folliculogenesis and on metabolic, genetic and epigenetic quality parameters of the oocyte and pre-implantation embryo. University of Antwerp
Chemopreventive or breast cancer promoting? A comparative transcriptomic, epigenetic and metabonomic study of isoflavones, tamoxifen and raloxifene in healthy breast tissue. Ghent University
Upon soy consumption, isoflavones reach exposure levels in human breast tissue at which ERβ agonistic, putative protective, effects may occur. Yet, the clinical implications of these findings require further investigation. This project aims to characterize the differential activation of estrogen-responsive genes between dietary isoflavones and chemopreventive therapeutics in women undergoing breast reduction surgery by a controlled dietary ...
Epigenetic effects induced by nanomaterials. KU Leuven
Tumor-microenvoronment interactions in multiple myeloma: regulation by epigenetic modifications and hypoxia. Vrije Universiteit Brussel
Investigation of epigenetic stability and safety of assisted reproduction technologies Vrije Universiteit Brussel
The epigenome is less stable than the genome (Bennett-Baker et al., 2003). Epimutations (i.e. modifications of the chromatin configuration or the DNA methylation pattern, resulting in altered gene expression) occur mostly in a stochastic manner and their incidence is dependent on genetic and environmental influences. Genomic imprinting is an epigenetic mechanism characterised by parent-specific marks at several ...
The high- throughput identification and validation of epigenetic biomarkers for cardiovascular disease. Ghent University
In the Western World, cardiovascular diseases (CVD) represent the most important cause of death. The interaction between aging, genetics and lifestyle in the development of CVD pints towards an epigenetic component. Therefore, a high- throughput epigenetic profiling of CVD will be performed, based on samples from the longitudinal Asklepios study. This may deepen the understanding of the molecular pathology of CVD