Towards a targeted therapy for diabetic neuropathy: a cross-sectional study and exercise training intervention to improve pathophysiological understanding. Ghent University
Approximately 50% of all patients with type 2 diabetes mellitus (T2DM) develop diabetic neuropathy (DNP), which leads to a decrease in muscle mass and strength. This sarcopenic effect can theoretically be attributed to a shift in muscle fiber type and a negative protein turnover, resulting from reduced mitochondrial function and inflammation. There are some studies that report a shift to a more anaerobic type IIx fibers in the case of T2DM, ...