Data-driven search for 3D facial traits determined by major gene effects in health and disease KU Leuven
In this project, we challenge the current paradigm shift in the post-genomics era that led to the transition from investigating monogenetic to polygenetic traits, and thus from rare major gene effects to common variants with weak effect. We hypothesise that many major gene effects among patients with complex phenotypes remain undiagnosed and that major gene effects in the so-called healthy population result in subclinical phenotypes that escape ...