Projects
Identification and validation of physiological substrates and interaction partners of PINK1 and LRRK2, 2 kinases linked to familial forms of Parkinson's disease. KU Leuven
Novel HIV inhibitors targeting the interaction between integrase and LEDGF/p75 KU Leuven
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Pancreatic cancer stem cells: the 'side population' as a new therapeutic target. KU Leuven
Metabolism without GLUT4, UCP1 and leptin: mRNA expression analysis in chicken. KU Leuven
When analysing gene expression of >20 tissues in mice, we discovered the phenomenon of “disallowed” genes (financially supported by FWO - G067212N). Last year, we started analysis of evolutionary conservation of “disallowed genes” by defining a core set of mRNA encoding genes that are commonly present in the genomes of humans, chickens, lizards and coelacanth, representing 4 major classes of vertebrate life. Taking human genes as reference ...
The 'Unusual' Distal Median Nerve Neuropathy: new insights in diagnose and treatment. KU Leuven
The ‘Unusual’ Distal Median Nerve Neuropathy: new insights in diagnose and treatment. From diagnose of concomitant pathologies in carpal tunnel disease To treatment possibilities in exceptional cases of distal median nerve neuropathy Concluding into final options with therapy resistent patients Implementing questions from the base into daily practice providing out-of-the-box thoughts to the practitioner. Congenital Carpal tunnel syndrome: de ...
“One Health” implications of the use of antibacterial agents in pet animals Ghent University
The PET-AMR project will investigate the “One Health” implications of the use of antibacterial agents in pet animals in Belgium. Five different research questions will be investigated through 5 corresponding work packages. The first question is “which antibiotics are used in dogs and cats, for which indications and in which quantity”. To answer this, up to 200 veterinary practices will be contacted to collect data to quantify the ...
The effect of aging on the regenerative capacity of the killifish Nothobranchius furzeri after traumatic brain injury KU Leuven
The brain deteriorates with advancing age, halting our cognitive abilities and our intellectual growth. Because of the advancements made in medical care, the human population has gained an increased life expectancy, that is unfortunately mirrored by an elevated number of elderly that suffer from age-related neuropathology. The energy-demanding brain is specifically prone to aging stressors, what eventually causes a loss of neurons and hence, ...
Identification of novel genetic and epigenetic mechanisms involved in the etiopathogenesis of orofacial clefts by means of exome sequencing, searching for DNA elements and p63 transcription factor binding sites KU Leuven
Cleft lip/palate (CL/P) is one of the most common birth defects in man (1 in 700 live births) and arises through a combination of genetic susceptibility factors andinfluences of / exposures to environmental risk factors in utero. In the identification of genetic causes of CL/P, only a limited number of cases is expected to be explained by mutations in the coding regions. These are presumed to be present in families with multiple OFC affected ...
Computational and Omics Analyses providing new Leads for improving Streptomyces lividans for Heterologous Protein Production KU Leuven
As the industrial and medical use of enzymes intensifies, so does the search for appropriate host organisms to produce these enzymes heterologously. In this respect, the bacterium Streptomyces lividans is increasingly attracting attention, mainly because of its favorable traits concerning protein secretion. This dissertation encompasses a contribution to the scientific community’s efforts to understand and modify S. lividans in order to ...