Towards the structural and molecular basis of pro-inflammatory signalling assemblies mediated by IL-23 and IL-12 Ghent University
Mammalian cellular development and regulation of the immune system crucially depend on appropriate signalling pathways initiated by dedicated cytokine-receptor assemblies at the cellsurface. The downside of such a key physiological activity is that native and mutant forms of cytokines and their receptors are often pivotal to the initiation and progression of inflammatory disorders, cellular malignancies and cancer. Interleukin-12 (IL-12) and ...