Publications
Chosen filters:
Chosen filters:
Absence of knockdown resistance suggests metabolic resistance in the main malaria vectors of the Mekong region University of Antwerp
Background As insecticide resistance may jeopardize the successful malaria control programmes in the Mekong region, a large investigation was previously conducted in the Mekong countries to assess the susceptibility of the main malaria vectors against DDT and pyrethroid insecticides. It showed that the main vector, Anopheles epiroticus, was highly pyrethroid-resistant in the Mekong delta, whereas Anopheles minimus sensu lato was ...
Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus populations of the Mekong region Institute of Tropical Medicine
ABSTRACT: BACKGROUND: In the Mekong region (Vietnam, Cambodia and Laos), a large investigation was conducted to assess the susceptibility of Anopheles species against DDT and pyrethroids. In this study, the resistance status of the potential malaria vectors An. vagus, An. sinensis, An. paraliae and An. peditaeniatus was assessed. METHODS: Bioassays were performed on field collected unfed female mosquitoes using the standard WHO susceptibility ...
First evidence of high knockdown resistance frequency in Anopheles arabiensis (Diptera: Culicidae) from Ethiopia Institute of Tropical Medicine
The status of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia. Among 240 mosquito samples from 15 villages of southwestern Ethiopia that were screened by allele-specific polymerase chain reaction for kdr mutations, the West African kdr mutation (L1014F) was detected in almost all specimens (98.5%), whereas the East African kdr mutation (L1014S) was ...
Presence and role of knockdown resistance in Anopheles species of Africa and the Mekong region Institute of Tropical Medicine
First evidence of high knockdown resistance frequency in anopheles arabiensis (diptera: Culicidae) from Ethiopia Ghent University University of Antwerp
Knockdown resistance in **Anopheles vagus**, **An. sinensis**, **An. paraliae** and **An. peditaeniatus** populations of the Mekong region University of Antwerp
Background In the Mekong region (Vietnam, Cambodia and Laos), a large investigation was conducted to assess the susceptibility of Anopheles species against DDT and pyrethroids. In this study, the resistance status of the potential malaria vectors An. vagus, An. sinensis, An. paraliae and An. peditaeniatus was assessed. Methods Bioassays were performed on field collected unfed female mosquitoes using the standard WHO susceptibility tests. In ...
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity Vrije Universiteit Brussel
Decreased adipose tissue oxygen tension and increased HIF-1α expression can trigger adipose tissue inflammation and dysfunction in obesity. Our current understanding of obesity-associated decreased adipose tissue oxygen tension is mainly focused on changes in oxygen supply and angiogenesis. Here, we demonstrate that increased adipocyte O2 demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia. Deletion of adipocyte Ant2 ...
The role of LEDGF/p75 in HIV replication Analysis of knockdown and knockout cell lines and translational implications KU Leuven
HIV, the causative agent of AIDS affects more than 34 million people worldwide. Controlling the HIV pandemic and ultimately curing HIV remains one of the major challenges in medicine. Although antiretroviral drugs have markedly changed the outcome of HIV infected patients, converting a deadly disease into a chronic infection, they are not without important problems and drawbacks. Even with the most effective antiretroviral drug combinations, ...
Pharmacological characterization of an antisense knockdown zebrafish model of dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine KU Leuven University of Antwerp
Dravet syndrome (DS) is one of the most pharmacoresistant and devastating forms of childhood epilepsy syndromes. Distinct de novo mutations in the SCN1A gene are responsible for over 80% of DS cases. While DS is largely resistant to treatment with existing anti-epileptic drugs, promising results have been obtained in clinical trials with human patients treated with the serotonin agonist fenfluramine as an add-on therapeutic. We developed a ...