Projects
Genetic analysis, manipulation and correction of molecular pathways of blood platelet formation and function. KU Leuven
Molecular genetic analysis of epileptic encephalopathies using whole exome sequencing. University of Antwerp
Molecular genetic analysis of Dopa-responsive dystonia. University of Antwerp
Molecular characterization of genetic events driving development of peripheral T cell lymphoma KU Leuven
Peripheral T cell lymphoma (PTCL) is a rare form of blood cancer. Currently, except for chemotherapy, there are no effective treatment options, and the long-term success of treatment with chemotherapy is limited. As a result, the survival rate is only 30%. Thus, there is a high need for new treatment options for these patients. To better understand this rare disease, we have done whole genome and transcriptome analysis on 28 PTCL tumors in ...
Genetic control and molecular regulation of temperature-dependent CO plasticity in plant meiosis. KU Leuven
Genetic control and molecular regulation of temperature-dependent CO plasticity in plant meiosis. KU Leuven
Meiotic recombination forms an essential aspect of plant reproductive development with major relevance for both evolution and crop breeding. Meiosis not only serves to halve the chromosome number, but also aims to reshuffle parental genomes to create novel allelic variability upon which selection can act. Overall, meiotic crossover (CO) designation is strictly controlled by the integrated action of several homeostasis mechanisms, thereby ...
Molecular characterization of genetic events driving development of peripheral T cell lymphoma KU Leuven
Peripheral T cell lymphoma (PTCL) is a form of blood cancer that develops from mature T cells, a kind of white blood cells. These T cells are growing uncontrollably, thereby forming a tumor that is mostly located in the lymph nodes. PTCL patients are currently treated with chemotherapy, but the chances of survival are only 30%. Therefore, there is a high clinical need for new therapeutic options for these patients. With this research project, ...