Array comparative genomic hybridization as a diagnostic tool for syndromic heart defects Vrije Universiteit Brussel KU Leuven
OBJECTIVES: To investigate different aspects of the introduction of array comparative genomic hybridization (aCGH) in clinical practice.
STUDY DESIGN: A total 150 patients with a syndromic congenital heart defect (CHD) of unknown cause were analyzed with aCGH at 1-Mb resolution. Twenty-nine of these patients, with normal results on 1Mb aCGH, underwent re-analysis with 244-K oligo-microarray. With a logistic regression model, we assessed ...