Projects
Structure based design of TIMP1 binding PET tracer for Multiple Sclerosis. KU Leuven
Computational methods have been great assets saving time and resources in de novo design of new drug candidatures or diagnostic probers. In this doctoral project, two novel challenging targets will be tackled through following two parallel research tracks: one related to the treatment of cancer while the other to diagnosis of neurological disorders. Concerning the first research track, PKD2 is one of three isoforms of the protein kinase D ...
GMP lab for production of PET tracers for clinical and translational research KU Leuven
Positron emission tomography (PET) is a molecular imaging technique in which small amounts of short-lived radioactive compounds (“PET tracers”) are administered and bind to specific targets (receptors, enzymes, transporters or other biomolecules) in the body. The expression of these targets can be visualized and quantified in vivo using a dedicated PET camera that detects the gamma-rays emitted upon decay of the injected ...
Development of a novel chemoenzymatic technology to generate radiofluorinated PET tracers Vrije Universiteit Brussel
for Positron Emission Tomography (PET) imaging. A previouslydeveloped Nb targeting Programmed Death Ligand 1 (PD-L1)
displays promising properties as a PET tracer for stratification and
prediction of treatment outcome of patients potentially eligible for
immune-therapy. Fluorine-18 (18F) is the most ideal PET
radionuclide for clinical ...
Prospective clinical diagnostic performance of the novel fibroblast imaging tracer 18F-AlF-FAPI-74 versus standard of care 18F-FDG PET/CT in inflammatory disorders and fever/inflammation of unknown origin. KU Leuven
Amino-acid PET based dose painting radiation therapy in glioblastoma patients Ghent University
Glioblastoma is the most aggressive and most common primary brain tumour in adults. Even with the current state-ofthe-
art treatment of postoperative combined radiation therapy (RT) and chemotherapy, the median survival is only 12-14
months. Therefore, there is an urgent need for alternative treatment strategies in glioblastoma patients. In this proposal,
the focus is ...
Motion compensation for PET in TOF-PET/CT and TOF-PET/MR brain imaging KU Leuven
In PET/CT or PET/MR brain imaging, images of the metabolism and anatomy of the patient are acquired. If the patient moves during the PET acquisition, then motion blurring is caused, the image quality is deteriorated, and an accurate clinical diagnosis might become impossible. Several research groups (including our own) have previously developed marker based methods to track the motion of the head, such that the motion can be compensated for ...
Development and evaluation of PET ligands for the in vivo visualisation of phosphodiesterase type 5 (PDE5). KU Leuven
Enabling SF5 introduction: Paving the way toward unexplored bioisosteres and novel PET radiotracers KU Leuven
Organofluorverbindingen nemen steeds meer een gepriviligieerde plaats in als kandidaat-medicijnen, diagnostische PET-tracers en agrochemicaliën. Concreet bevatte ongeveer de helft van de door de FDA goedgekeurde kleine molecule geneesmiddelen in 2018 een of meer fluoratomen. De recente ontwikkeling van een veelheid aan stabiele fluortransfer reagentia heeft het arsenaal aan fluorbevattende verbindingen sterk doen uitbreiden. Niettegenstaande ...