Publications
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[Supernumerary teeth in the maxilla and mandible-an interdisciplinary challenge. Part 1: epidemiology, etiology, classification and associated complications]. KU Leuven
Supernumerary teeth develop in addition to the normal dentition and are a therapeutic challenge for pedodontists, orthodontists and oral surgeons alike. Therefore, interdisciplinary treatment concepts are needed for the benefit of the patient. In the present, two-parted literature review on supernumerary teeth, current classification, associated complications, diagnostic steps and different therapeutic approches are presented and discussed. ...
Estimating emergence sequences of permanent teeth in Flemish schoolchildren using interval-censored biplots: a graphical display of tooth emergence sequences Hasselt University KU Leuven
Objectives: The aim of the present study was to investigate the pattern of emergence of permanent teeth using nonparametric techniques. Materials and methods: Data were obtained from the Signal-Tandmobiel (R) project, a 6-year prospective dental study conducted in Flanders (Belgium) in which 4468 primary school children born in 1989 were annually examined. A new exploratory method for interval-censored data, the IC-biplot, was applied to ...
A manually controlled new device for punctuate mechanical stimulation of teeth during functional magnetic resonance imaging studies KU Leuven
AIM: To design a simple and affordable device that could apply standardized mechanical punctuate stimuli to trigger the periodontal mechanoreceptors during functional magnetic resonance imaging (fMRI). MATERIAL AND METHODS: A new manually controlled device using von Frey monofilaments was tested on a phantom and on eight volunteers. Four block design paradigms with different timing were compared. Teeth 11, 12, 13, 21, 22, 23 and the thumb were ...
The influence of 3D-CBCT on diagnosis and therapy for surgical interventions of impacted teeth and oral implants KU Leuven
For many decades two-dimensional radiographs have been considered as the primary diagnostic tool in oral health care, yet the introduction o f three-dimensional imaging has taken a giant leap forward. This techniq ue offers a series of benefits for clinicians and patients at the expens e of an increased dose. In the present thesis, we aimed to provide infor mation on the role of CBCT in the surgical management of patients with i mpacted ...
Characterization of spontaneous cell death in monolayer cultures of primary hepatocytes Vrije Universiteit Brussel
Monolayer cultures of primary hepatocytes, isolated from freshly removed livers, represent widely used in vitro tools in the area of liver physiology and pathology, pharmacology and toxicology. However, a major shortcoming of these systems is that they cope with dedifferentiation, which is accompanied by spontaneous cell death. The goal of the present study was to elucidate the mechanisms that drive the process of self-generated cell demise in ...
Exploring the impact on primary care mental health practitioners of the death of a patient by suicide: An IPA study KU Leuven
Objectives There have been numerous qualitative studies into the impact of the death of a patient by suicide on clinicians, but the majority of studies have focussed on psychiatrists and psychologists, primarily in inpatient or secondary care settings. To date, little has been done to explore the impact of such deaths on other mental health practitioners working in primary care, such as those working in Improving Access to Psychological ...
Prevention of sudden death in heart failure with reduced ejection fraction: do we still need an implantable cardioverter-defibrillator for primary prevention? Hasselt University
Sudden death is a devastating complication of heart failure (HF). Current guidelines recommend an implantable cardioverter-defibrillator (ICD) for prevention of sudden death in patients with HF and reduced ejection fraction (HFrEF) specifically those with a left ventricular ejection fraction <= 35% after at least 3 months of optimized HF treatment. The benefit of ICD in patients with symptomatic HFrEF caused by coronary artery disease has ...
Development and external validation of prediction models to predict implantable cardioverter-defibrillator efficacy in primary prevention of sudden cardiac death KU Leuven
AIMS: This study was performed to develop and externally validate prediction models for appropriate implantable cardioverter-defibrillator (ICD) shock and mortality to identify subgroups with insufficient benefit from ICD implantation. METHODS AND RESULTS: We recruited patients scheduled for primary prevention ICD implantation and reduced left ventricular function. Bootstrapping-based Cox proportional hazards and Fine and Gray competing risk ...