Projects
Multi-parameter analysis of single nanoparticles for biomedical applications Ghent University
In a number of biomedical applications it is important to detect the amount of entities such as biomolecules or gold NPs that are bound to “core” nanoparticles (liposomes, exosomes or solid nanoparticles). However, the present measurement techniques are unable to accurately determine this number as well as the particle-to-particle variation. In this project, sensitive measurements of the size, intensity and zeta-potential of single ...
Design of solid-state crosslinkable gelatins for biomedical applications Ghent University
The proposal addresses bottlenecks associated with crosslinking of gelatin derivatives after
processing through electrospinning and spraydrying. Indeed, the state-of-the-art does not permit
crosslinking in solid state. Hydrogel precursors will therefore be designed with flexible, urethanebased
spacers separating the backbone from the crosslinkable moieties, which will result in a
paradigm shift towards the ...
Interpretable predictive models for biomedical applications with structured outputs KU Leuven
In Intensive Care Medicine, bleeding edge technology is constantly applied to treat patients. In particular, it prioritizes critically ill patients, as they are suffering from life threatening conditions which may cause mortality or severe consequences. In order to improve their chances, in parallel to the technological advance, we will apply Machine Learning methods in this context. More specifically, we will employ Semi-Supervised and ...
Design and development of a multimodal synchrotron based methodology for 3D nano-analysis for biomedical and environmental applications Ghent University
The goal of this research project is the development of novel analytical methods for nano-analysis
of biomedical and environmental samples using synchrotron radiation (SR) based X-ray imaging
methodologies. The envisaged applications comprise optimization of ovarian cancer treatment
(Prof dr W. Ceelen) and assessing the influence of deep-sea mining on the marine eco-system (Prof
dr A. Van Reusel).
X-ray based ...
Applied biomedical research on spina bifida. KU Leuven
We propose a research project to restore spina bifida anatomically endoscopically in two layers, via one-port fetoscopy instead of via hysterotomy. The rationale for this is that the "open" approach to the uterus compromises both in the index and subsequent pregnancies.
Daphnia: from ecological to biomedical microbiome model in the context of hypoxia KU Leuven
Host-associated microbiomes relate to the microbiota that live inside and on the surfaces of hosts. The microbial community is not a random collection of organisms but is the result of complex interactions between microbiota within the host and between the host and the microbiota. These interactions are mediated by host physiology and environmental factors. The host-associated microbiota is currently considered as a novel factor in host ...
Boosting biomedical imaging data analysis via advanced machine learning KU Leuven
Mass spectrometry imaging (MSI) is a promising, label-free molecular imaging technology, which enables mapping the spatial distribution of hundreds to thousands of biomolecules in a tissue within a single experiment. Additionally, as it is a label-free and untargeted molecular imaging technology, it does not require prior knowledge about the tissue or target-specific reagents. Due to those outstanding characteristics, MSI is becoming ...
Purchase steam autoclave central kitchen Department of Biomedical Molecular Biology Ghent University
This application for basic equipment concerns funding for a steam autoclave for the central kitchen of our department. This is a really basic instrument crucial for the general functioning of any biochemical-biomedical laboratory. The machine will be used for autoclaving liquids (and glass work) for the research groups of the departments WE14, WE10, WE02 and GE01 working in our building.
Development of magnetic nanoparticles for biomedical applications KU Leuven
The objective of this project is to design and synthesize magnetic nanoparticles with biocompatible coatings to which therapeutic molecules can be attached via a thermo-sensitive covalent bond. By applying an external alternating magnetic field (AMF), the superparamagnetic nanoparticles will generate heat, resulting in the breaking of the thermo-sensitive bonds. This will trigger the release of the attached organic moiety and therefore the ...