Gene therapeutic intervention during ex vivo lung perfusion as a platform to modulate human lung disease KU Leuven
Lung transplantation (LTx) is the ultimate therapy to treat patients suffering from for end-stage lung disease. Unfortunately, LTx is accompanied by a low survival rate. Primary Graft Dysfunction (PGD) is a severe form of acute lung injury after LTx that is a major cause of poor survival. Although much progress has been made in understanding the risks and mechanisms of PGD, there is still no effective treatment. Ex-vivo lung perfusion (EVLP) ...