Direct integrative single-cell sequencing of Acute Lymphoblastic Leukemia patients KU Leuven
Leukemia is a complex disease caused by the accumulation of oncogenic lesions in developing lymphoid cells. This hematologic malignancy shows extensive genetic intra-tumoral heterogeneity. However, we still do not fully understand how it develops, the exact type of cells that compose it and the sensitivity of the different cells to the treatment. In order to dissect heterogeneity, it is essential to perform studies with single-cell ...