Publications
Lentiviral vectors for anti-tumor immunotherapy Vrije Universiteit Brussel
Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis Hasselt University Ghent University
RNA in cancer immunotherapy Vrije Universiteit Brussel
Recent advances in the manufacturing, modification, purification and cellular delivery of ribonucleic acid (RNA) have enabled the development of RNA-based therapeutics for a broad array of applications. The approval of two SARS-CoV-2-targeting mRNA-based vaccines has highlighted the advances of this technology. Offering rapid and straightforward manufacturing, clinical safety and versatility, this paves the way for RNA therapeutics to expand ...
World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guideline update - XIII - Oral immunotherapy for CMA - Systematic review Vrije Universiteit Brussel
Background: Allergy to cow's milk is the most common food allergy in infants and it is usually outgrown by 5 years of age. In some individuals it persists beyond early childhood. Oral immunotherapy (OIT, oral desensitization, specific oral tolerance induction) has been proposed as a promising therapeutic strategy for persistent IgE-mediated cow's milk allergy. We previously published the systematic review of OIT for cow's milk allergy (CMA) ...
TNF-alpha-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy Vrije Universiteit Brussel University of Antwerp
Immune checkpoint blockade (ICB) of the PD-1 pathway revolutionized the survival forecast for advanced non-small cell lung cancer (NSCLC). Yet, the majority of PD-L1+ NSCLC patients are refractory to anti-PD-L1 therapy. Recent observations indicate a pivotal role for the PD-L1+ tumor-infiltrating myeloid cells in therapy failure. As the latter comprise a heterogenous population in the lung tumor microenvironment, we applied an orthotopic ...
Non-viral siRNA delivery to T cells : challenges and opportunities in cancer immunotherapy Ghent University
Delayed immune-related adverse events with an PD-1-based immunotherapy in melanoma Vrije Universiteit Brussel
Adjuvanting allergen extracts for sublingual immunotherapy : calcitriol downregulates CXCL8 production in primary sublingual epithelial cells Ghent University
Supporting allergen-specific immunotherapy by inhibition of Janus kinases Vrije Universiteit Brussel
Allergen-specific immunotherapy (AIT) is the only disease-modifying and curative treatment for allergic diseases. While in selected indications such as Hymenoptera venom allergy the curative success of AIT is impressingly high, in other disease manifestations it only reduces the symptoms to a certain extend in a fraction of patients. Key problems leading to a reduced efficacy of AIT seem to partly depend on local inflammatory processes that ...