Projects
Population Balance Model-Based Optimization of Deracemization Processes for Pharmaceutical Applications KU Leuven
Chirality has different implications in pharmaceuticals, as in some cases, enantiomers exhibit different biological activities and most of the times, only one enantiomer (eutomer) possesses the desired effect. For example, ibuprofen, which is sold as a racemate (1:1 mixture of the two enantiomers R- and S-) under the trade names Advil, Motrin etc. is a drug able to treat pain, fever and inflammation. Even if only the S- enantiomer is ...
Model-based characterization of the mechanical niche of mouse fetal liver hematopoietic stem cells. KU Leuven
Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) would theoretically provide an inexhaustible pool of HSCs, suitable for transplantation or for the generation of blood cells for transfusion. Although immature HSCs can be generated from PSCs, they do not robustly engraft and cannot yet be used to generate large numbers of hematopoietic cells.
The behavior of somatic stem cells is regulated by their ...
EVIT: Model-based experimental-virtual testing Ghent University
This project will design a methodology for generating virtual and experimental test scenarios for the control algorithms of mechatronic machines and vehicles. These test scenarios will help to develop a controller that achieves the required performance under all conditions.
The concrete project goals are:
- Developing a methodology and supporting software tools for the generation of all possible scenarios in which a control ...
Universal Design and design practice: universal design patterns as a model and support for designing integrally and inclusively for all. Hasselt University
Combining acoustic sensor data with physical models for virtual sensing in dynamic and mechatronic system design and analysis. KU Leuven
Sound and vibrations are all around us and constantly impact our everyday lives, both consciously and unconsciously. The way something feels and sounds contributes enormously to its perceived quality. For this reason the design of the acoustic and vibrational characteristics of products is becoming ever more important.
The physical laws that govern sound and vibrations have already been known for a long time, but even for moderately ...
Development of surrogate-assisted algorithms for combined design and trajectory optimization of dynamic mechatronic systems Ghent University
Up until recently a sequential approach has been pursued for model-based design of dynamic mechatronic systems, where first the system is optimized for static performance measures after which its functionality is enhanced by optimizing its control trajectory. However, this impedes finding systems with concurrent optimal design and trajectory. To address this, multi-disciplinary integrated design methods – co-design – have appeared that treat ...
Selection, design and control of electromagnetic torque ripple reduction for drivetrains (Torque-Ripple_Reduction) Ghent University
This project aims to help the industry to achieve higher performing yet cost-efficient drive systems by evaluating new innovative concepts and new controller designs for torque ripple suppression. The models developed on the basis of these concepts and the new controller models will form the basis of a model-based design tool for drive systems with torque ripple suppression mechanisms. This project will build on the results and knowledge ...
Computer-aided orthosis design to improve walking performance in children with Duchenne muscular distrophy and cerebral palsy KU Leuven
Orthoses have the potential to improve walking abilities for children
with neuromuscular disorders such as Duchenne muscular dystrophy
and cerebral palsy (CP). Yet selecting the optimal orthoses for a
patient is challenging given the heterogeneity of gait impairments. As
a result, improvements in walking due to orthotic use are very
variable. For example, orthoses improved gait speed in 48% but the
walking ...
Design and design automation of analog and mixed-signal integrated circuits KU Leuven
Microelectronic/nanoelectronic integrated circuits are the underlying technology for the many ICT applications that increasingly impact our daily lives: computing, communication, multimedia, entertainment, transport, healthcare, etc. While more and more applications are becoming digital in nature, analog and mixed analog-digital integrated circuits remain an essential part in electronic systems for the countless applications that interact ...