Unveiling the role of FOXG1 in neurodevelopment and disease: a comprehensive analysis using neural organoids, imaging and Single Cell Sequencing Ghent University
This study aims to investigate the role of FOXG1 in neurodevelopment and disease. The forkhead box G1 protein, encoded by FOXG1, acts as a transcriptional repressor primarily expressed within the brain. It is essential for the development of the forebrain and forebrain derived structures. Furthermore, fine-tuned FOXG1 levels are essential for balancing excitatory and inhibitory neuron populations. Loss-of-function (LoF) of FOXG1 is associated ...