Projects
Targeting CD70-positive cancer-associated fibroblasts to improve chemotherapy and alleviate the immuno-suppressive tumor microenvironment in advanced colorectal cancer. University of Antwerp
Tackling the challenges in selective and potent targeting of Tumor Micro-Environment Proteases. University of Antwerp
Next generation cancer immunotherapy: Targeting the tumor microenvironment. Vrije Universiteit Brussel
Tumor vessel normalization by targeting endothelial cell metabolism: a novel strategy to improve combination chemo/immuno-therapies against cancer. KU Leuven
The aim of this project is to develop and validate an entirely innovative anti-angiogenic strategy of inducing “tumor vessel normalization” by interfering with endothelial cell (EC) metabolism, in order to improve combinations with existing (chemo-) or emerging (immuno-)therapies for the most common vascularized cancer types, and thereby maximize treatment efficacy and offer an answer to pressing therapeutic needs of cancer patients.
...Targeting endothelial metabolism: a novel anti-angiogenic approach for tumor therapy. KU Leuven
Targeting the Hippo pathway for cancer therapy: Discovering endogenous tumor suppressor mechanisms KU Leuven
Cancer is a leading cause of death worldwide, currently responsible for about 10 million deaths every year. Unfortunately, despite extensive research within this field, how cancer originates is not completely understood. The predominant theory about the genesis of cancer suggests that it arise when cells accumulate a certain amount of driver mutations. These mutations reprogram normal cells into cancerous cells, through progressive changes ...
Targeting tumor microenvironment to counteract cancer progression Ghent University
The tumor microenvironment (TME) dictates cancer progression. New therapeutic approaches with focus on TME represent an urgent medical need. The host lab acquired unique models of the TME and identified compounds that interfere with the TME. It’s my aim to use advanced preclinical models, pharmacologic and genetic tools to counteract cancer progression through targeting of the TME.
Targeting eicosanoid metabolism to overcome tumor immunosuppression Flanders Institute for Biotechnology
Spin-off incubation track for the development of tumor environment targeting drugs for highrisk metastatic cancers Ghent University
We have discovered, profiled and patented three series of novel anti-invasive small molecules with potential as first-in-class therapeutic agents that in combination with antiproliferative drugs could substantially reduce morbidity and mortality in solid tumours with a high risk of metastasis. The mechanism of action of the compounds has been differentiated from that of compounds under development by others. A broad UGent consortium is ...