Metabolic reprogramming in critical illness

Our research focuses on critical illness, what can be defined as any life-threatening condition for which the body requires intensive medical care to prevent death. One of the hallmarks of critical illness is the development of a hypercatabolic response which cannot be counteracted by nutrition alone. This project wants to unravel the observed metabolic dysregulation and identify how nutrition can play either a detrimental or beneficial role in the recovery process of critical illness. We will address our questions in a clinically relevant mouse model of intensivecare-supported critical illness and translate if possible to the human patient in retrospective and prospective studies.