Organisation
Laboratory of Biosignaling & Therapeutics
Division
The Laboratory of Biosignaling & Therapeutics investigate cellular signal transduction pathways at the molecular level. One of our major goals is to identify and develop novel biomarkers or therapeutic targets for human diseases. The current focus is on the (mis)regulation of chromatin signaling, DNA repair and cell division in cancer cells by enzymes known as protein phosphatases.
Current researchers
1 - 10 of 11 results
- Mathieu Bollen (Responsible)
- Joao Barbosa (Member)
- Monique Beullens (Member)
- Mathieu Bollen (Member)
- Xinyu Cao (Member)
- Zander Claes (Member)
- Monica Dos Santos Ferreira (Member)
- Marloes Jonkhout (Member)
- Sarah Lemaire (Member)
- Aleyde Van Eynde (Member)
Projects
1 - 10 of 41
- Phospho-regulation at the crossroads of cell proliferation and DNA-damage controlFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Coordination of cell-cycle progression and DNA-damage repair by the protein phosphatase-1 regulator NIPP1From1 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Life-course regulators of protein phosphatase-1From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Host cell phosphatases in the life cycle of DNA virusesFrom1 Oct 2020 → TodayFunding: BOF - projects
- Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymesFrom14 Oct 2019 → 14 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of histone modifications in the life cycle of AAV2 and recombinant AAV-mediated transgene expressionFrom1 Oct 2019 → 27 Jan 2023Funding: FWO Strategic Basic Research Grant, BOF - doctoral mandates
- Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1From3 Sep 2019 → 10 Jan 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular timers of the spindle assembly checkpointFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 135
- Epigenetic mechanisms in development, inheritance and disease(2012)
Authors: Nikki Minnebo, Aleyde Van Eynde, Mathieu Bollen
Pages: 19 - 40 - Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells (Retracted article. See vol. 292, pg. 12786, 2017)(2013)
Authors: Cenk Kig, Monique Beullens, Lijs Beke, Aleyde Van Eynde, Johannes T Linders, Dirk Brehmer, Mathieu Bollen
Pages: 24200 - 24212 - The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets(2010)
Authors: Nele Van Dessel, Lijs Beke, Janina Goernemann, Nikki Minnebo, Monique Beullens, Aleyde Van Eynde, Mathieu Bollen
Pages: 7500 - 12 - Structural basis of substrate discrimination and integrin binding by autotaxin(2011)
Authors: Silvia Jansen, Maria Andries, Mathieu Bollen
Pages: 198 - 204 - Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171)(2018)
Authors: HeloIse Proquin, Marlon J Jetten, Marloes Jonkhout, Luis G Garduno-Balderas, Jacob J Briede, Theo M de Kok, Yolanda I Chirino, Henk van Loveren
Pages: 153 - 165 - Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts
Authors: Silvia Jansen, Mathieu Bollen
- Improving In Vitro Culture of Human Male Fetal Germ Cells(2021)
Authors: Monica Dos Santos Ferreira
- MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells(2015)
Authors: Shannah Boens, Aleyde Van Eynde, Monique Beullens, Mathieu Bollen
- The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2(2018)
Authors: Iris Verbinnen, Aleyde Van Eynde, Mathieu Bollen
Pages: 18031 - 18039 - Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks(2018)
Authors: Dan Wu, Monique Beullens, Aleyde Van Eynde, Mathieu Bollen