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Researcher
Jan Tytgat
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Toxicology and Pharmacology (Division)
Responsible
From1 Jan 2012 → Today - Toxicology and Pharmacology (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 26
- Improving Bees' Resilience to Stressors by Restoring Harmony and BalanceFrom1 Jun 2023 → TodayFunding: Horizon Europe - Food, Bioeconomy, Natural Resources, Agriculture and Environment
- Functional characterisation of Transient Receptor Potential Vanilloid (TRPV2) as a potential new target for endometrial cancerFrom1 Oct 2021 → TodayFunding: FWO junior postdoctoral fellowship
- Functional characterisation of Transient Receptor Potential Vanilloid (TRPV2) in uterine stroma - a potential new target for endometrial cancerFrom1 Mar 2020 → 28 Feb 2021Funding: BOF - postdoctoral mandates
- Ion channel ligands with unique selectivityFrom1 Jan 2020 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- PROBIO PROspection for BIOactive compounds in the North SeaFrom1 Nov 2019 → 30 Apr 2022Funding: VLAIO - Blue Cluster - ICON
- Targeting cannabinoid receptor signaling for drug discovery and characterization: A focus on CB1 and CB2 cannabinoid receptors and GIRK1/GIRK2 potassium channelsFrom19 Sep 2019 → 5 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Conopeptides as tools for studying pacemaker channels and for the development of novel cardiovascular drugsFrom9 Jan 2019 → 12 Dec 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Discovery and mechanism of action of novel hEag1 potassium channel lead molecules with anti-cancer activity.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Molecular elucidation of the unique gating behavior of cardiac ion channels thanks to their interaction with conopeptides.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- The epigenetic effects of air pollutants on human Amniotic Fluid Stem Cells (hAFSCs)From1 Nov 2017 → 28 Jul 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 302
- The Sobering Sting: Oleoyl Serotonin Is a Novel Stephanoconus Snail Venom-Derived Antagonist of Cannabinoid Receptors That Counteracts Learning and Memory Deficits(2024)
Authors: Steve Peigneur, Jan Tytgat
- Bombé, an undetermined substance that caused an outbreak of illicit drug use in Kinshasa, Democratic Republic of the Congo(2023)
Authors: Radu Corneliu Duca, Jan Tytgat, Benoit Nemery de Bellevaux
Pages: 1055 - 1058 - Histamine Receptors: Ex Vivo Functional Studies Enabling the Discovery of Hits and Pathways(2023)
Authors: Steve Peigneur, Jan Tytgat
- Immunosuppressive effects of new thiophene-based KV1.3 inhibitors(2023)
Authors: Steve Peigneur, Jan Tytgat
- New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel(2023)
Authors: Jan Tytgat, Steve Peigneur
- Targeting cannabinoid receptor signaling for drug discovery and characterization: A focus on CB1 and CB2 cannabinoid receptors and GIRK1/GIRK2 potassium channels(2023)
Authors: Dongchen An, Jan Tytgat, Steve Peigneur
- Structure-function relationship of new peptides activating human Nav1.1(2023)
Authors: Steve Peigneur, Jan Tytgat
- Heterologous expression of the α-Ktx Ts7 and its functional evaluation on Kv channels and CD4+T cell differentiation(2023)
Authors: Jan Tytgat
Pages: S230 - S230 - Methionine-isoleucine dichotomy at a key position in scorpion toxins inhibiting voltage-gated potassium channels(2023)
Authors: Steve Peigneur, Jan Tytgat
- Design of New Potent and Selective Thiophene-Based K(V)1.3 Inhibitors and Their Potential for Anticancer Activity (vol 14, 2595, 2022)(2023)
Authors: Steve Peigneur, Jan Tytgat