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Researcher
Bart Hens
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Drug Delivery and Disposition (Division)
Member
From1 Oct 2012 → 1 Nov 2020
Projects
1 - 3 of 3
- Towards a deeper understanding of physiological factors affecting drug and formulation behavior in the human gastrointestinal tractFrom1 Oct 2018 → 2 Nov 2020Funding: FWO fellowships
- Exploring physiological factors affecting drug and formulation behavior in the human gastrointestinal tractFrom1 Jan 2018 → 31 Dec 2018Funding: BOF - Other initiatives
- Development of biorelevant in vitro models as evaluation of supersaturating drug delivery systems based on in vivo characterization in humans.From1 Oct 2012 → 31 Dec 2016Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 42
- Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications(2020)
Authors: Patrick Augustijns, Tim Vanuytsel, Jan Tack, Bart Hens
- Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants(2020)
Authors: Bart Hens
- Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity(2020)
Authors: Suzanne Kaptein, Sofie Jacobs, Lana Langendries, Laura Seldeslachts, Sebastiaan ter Horst, Laurens Liesenborghs, Bart Hens, Valentijn Vergote, Elisabeth Heylen, Rana Abdelnabi, et al.
Pages: 26955 - 26965 - Using Physiologically Based Pharmacokinetic Modeling to Assess the Risks of Failing Bioequivalence Criteria: a Tale of Two Ibuprofen Products(2020)
Authors: Bart Hens
- Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola(R)on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)(2020)
Authors: Bart Hens, Patrick Augustijns
- Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives(2020)
Authors: Bart Hens
- Biopredictive in vitro testing methods to assess intestinal drug absorption from supersaturating dosage forms(2020)
Authors: Bart Hens, Patrick Augustijns
- Exploring the Impact of Real-Life Dosing Conditions on Intraluminal and Systemic Concentrations of Atazanavir in Parallel With Gastric Motility Recording in Healthy Subjects(2020)
Authors: Bart Hens, Imke Masuy, Jan Tack, Patrick Augustijns
Pages: 66 - 76 - A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP(2020)
Authors: Bart Hens
- Mechanistic Deconvolution of Oral Absorption Model with Dynamic Gastrointestinal Fluid to Predict Regional Rate and Extent of GI Drug Dissolution(2020)
Authors: Bart Hens