Perturbation of apolipoprotein E4 activity in Alzheimer’s disease pathology using single-domain antibodies.

Apolipoprotein E4 (apoE4) is the strongest genetic risk factor for Alzheimer’s disease (AD). However, the exact mechanisms by which apoE4 contributes to AD pathology remain incompletely understood. Single-domain antibodies (nanobodies) are powerful tools to gain new mechanistic insights into protein function. In this project, apoE targeting nanobodies were developed as a toolbox to study apoE4.

Keywords:Alzheimer’s disease, Apolipoprotein E4, nanobody

Disciplines:Molecular and cell biology not elsewhere classified, Molecular physiology, Pathophysiology, Stem cell biology, Neurological and neuromuscular diseases