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Researcher
Kurt Vermeire
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jul 2002 → Today - Immunobiology (Rega Institute) (Lab)
Member
From1 Oct 1999 → 30 Jun 2002
Projects
1 - 10 of 27
- The role of the trigger factor chaperone in protein sorting and secretory targeting, Acronym: TFaSTFrom1 Nov 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Characterization of protein translocation inhibitors of the ER Sec61 protein-conducting channelFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structural dynamics of secretory protein sorting, targeting, translocation (DynamicSTarT)From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Structural study and integrative modelling of the yeast Sin3/Rpd3 histone deacetylase complexesFrom7 Oct 2022 → TodayFunding: FWO fellowships
- Study of cellular factors involved in Respiratory Syncytial Virus (RSV) infectionFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structural dynamics basis of function in the SecB chaperoneFrom19 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Characterization of novel antibiotics against bacterial protein secretion.From1 Apr 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The construction of biologically contained filovirus systems and their purposes in antiviral compound screening and receptor binding associated studies.From18 Jan 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Non-folding signals and their decoding by chaperones in the secretory pathwayFrom27 Sep 2021 → 27 Sep 2025Funding: Own budget, for example: patrimony, inscription fees, gifts
- Cryo-EM study of a CADA-stalled human CD4 protein nascent chain in the Sec61 ER transloconFrom1 Jul 2021 → 31 Dec 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 69
- Sec61-targeted inhibitors of viral polyprotein import into the ER as antiviral drugs against orthoflaviviruses(2025)
- Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency.(2025)Published in: Cell ReportsISSN: 2211-1247Issue: 12Volume: 44Pages: 116642
- Design, synthesis and biological evaluation of a novel series of conjugates of N1-(phosphonoalkyl)-1,2,3-triazoles and N3-benzyl-6-bromoquinazoline-2,4-diones with anti-RSV activity(2025)Published in: Antiviral ResISSN: 0166-3542Volume: 244
- Effect of the Bacterial Chaperones SecB and Trigger Factor (TF) on the Folding Dynamics and In Vitro Translocation of Cytoplasmic and Secretory Model Proteins(2025)Published in: International Journal of Molecular SciencesISSN: 1661-6596Issue: 23Volume: 26Pages: 11485
- The Chiral 5,6-Cyclohexane-fused Uracil Ring-System: a Molecular Platform with Promising Activity against SARS-CoV-2(2025)Published in: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 286
- Rough microsomes isolated from snap-frozen canine pancreatic tissue retain their co-translational translocation functionality(2025)Published in: Biology Methods & ProtocolsISSN: 2396-8923Issue: 1Volume: 10
- Generation of Biologically Contained Marburg Virus.(2024)Pages: 155 - 164
- The endoplasmic reticulum (ER): a crucial cellular hub in flavivirus infection and potential target site for antiviral interventions(2024)Published in: npj VirusesISSN: 2948-1767Issue: 1Volume: 2
- Entry inhibitors for human respiratory virus SARS-CoV-2.(2023)
- Visualising SARS-CoV-2 infection of the lung in deceased COVID-19 patients(2023)Published in: EBioMedicineISSN: 2352-3964Issue: juni 2023Volume: 92Pages: 1 - 20
Patents
1 - 1 of 1