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Researcher
Jan Balzarini
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2016
Projects
1 - 6 of 6
- Exploration of carbohydrate-binding agents and (co)receptor inhibitors directed against HIV entry.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Exploration of the role of HIV envelope glycans on virus entry and the antiviral activity of carbohydrate-binding agents (CBAs)From29 Sep 2011 → 30 Sep 2015Funding: FWO fellowships
- The Rev-dependent nucleocytoplasmatic mRNA transport as a new target for anti-HIV therapyFrom1 Jan 2011 → 2 Jun 2015Funding: IWT personal funding - strategic basic research grants
- Viral infections: molecular insights, targets for intervention and drug developmentFrom1 Nov 2010 → 31 Oct 2018Funding: BOF - Concerted Research Project from 1994
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analoguesFrom1 Jun 2008 → 2 Dec 2013Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 546
- Synthesis and Evaluation of Prodrugs of alpha-Carboxy Nucleoside Phosphonates(2022)
Authors: Jan Balzarini
- Enantiocontrolled Preparation of Upsilon-Substituted Cyclohexenones: Synthesis and Kinase Activity Assays of Cyclopropyl-Fused Cyclohexane Nucleosides(2022)
Authors: Jan Balzarini
- Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure-Activity Relationship of a Scaffold Bearing a Five-Membered Ring System(2022)
Authors: Jan Balzarini, Sandra Liekens
- Skin Damages-Structure Activity Relationship of Benzimidazole Derivatives Bearing a 5-Membered Ring System(2020)
Authors: Jan Balzarini, Sandra Liekens
- Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold(2020)
Authors: Jan Balzarini, Sandra Liekens
- Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization(2020)
Authors: Jan Balzarini, Dominique Schols
- Synthesis, characterization and anti-HIV activity of polycarboxylic [60]fullerene derivatives obtained in the reaction of C60Cl6 with a hydroquinone ethere(2020)
Authors: Jan Balzarini, Dominique Schols
- Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity(2020)
Authors: Jan Balzarini, Dominique Schols
Pages: 1179 - 1182 - Synthesis, Biological Evaluation and Ligand Based Pharmacophore Modeling of New Aromatic Thiosemicarbazones as Potential Anticancer Agents(2019)
Authors: Jan Balzarini
Pages: 139 - 149 - Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity(2019)
Authors: Sam Noppen, Sandra Liekens, Jan Balzarini
Pages: 390 - 398
Patents
1 - 10 of 10
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Novel anti-cancer thiophene compounds (Inventor)
- Pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- New pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer (Inventor)
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Anti-cancer compounds (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)