Researcher
Jan Balzarini
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2016
Projects
1 - 6 of 6
- Exploration of carbohydrate-binding agents and (co)receptor inhibitors directed against HIV entry.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Exploration of the role of HIV envelope glycans on virus entry and the antiviral activity of carbohydrate-binding agents (CBAs)From29 Sep 2011 → 30 Sep 2015Funding: FWO fellowships
- The Rev-dependent nucleocytoplasmatic mRNA transport as a new target for anti-HIV therapyFrom1 Jan 2011 → 2 Jun 2015Funding: IWT personal funding - strategic basic research grants
- Viral infections: molecular insights, targets for intervention and drug developmentFrom1 Nov 2010 → 31 Oct 2018Funding: BOF - Concerted Research Project from 1994
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analoguesFrom1 Jun 2008 → 2 Dec 2013Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 558
- Synthesis and Evaluation of Prodrugs of alpha-Carboxy Nucleoside Phosphonates(2022)Published in: Journal of Organic ChemistryISSN: 0022-3263Issue: 21Volume: 87
- Enantiocontrolled Preparation of Upsilon-Substituted Cyclohexenones: Synthesis and Kinase Activity Assays of Cyclopropyl-Fused Cyclohexane Nucleosides(2022)Published in: International Journal of Molecular SciencesISSN: 1661-6596Issue: 17Volume: 23
- Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure-Activity Relationship of a Scaffold Bearing a Five-Membered Ring System(2022)Published in: AntioxidantsISSN: 2076-3921Issue: 2Volume: 11
- γ-Non-Symmetrically Dimasked TriPPPro Prodrugs as Potential Antiviral Agents against HIV(2021)Published in: ChemMedChemISSN: 1860-7179Issue: 3Volume: 16Pages: 499 - 512
- Prodrugs of γ-Alkyl-Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase(2020)Published in: Angewandte Chemie - International EditionISSN: 1433-7851Issue: 49Volume: 59Pages: 22063 - 22071
- γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals(2020)Published in: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 22Volume: 63Pages: 13745 - 13761
- Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity(2020)Published in: Chemical CommunicationsISSN: 1359-7345Issue: 70Volume: 56Pages: 10203 - 10206
- Skin Damages-Structure Activity Relationship of Benzimidazole Derivatives Bearing a 5-Membered Ring System(2020)Published in: MoleculesISSN: 1420-3049Issue: 18Volume: 25
- Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents(2020)Published in: Bioorganic ChemistryISSN: 0045-2068Volume: 101
- Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold(2020)Published in: MoleculesISSN: 1420-3049Issue: 7Volume: 25
Patents
1 - 10 of 10
- Novel anti-cancer thiophene compounds
- Phosphonucleosides useful in the treatment of viral disorders
- Pradimicin derivatives for the treatment of diseases caused by kinetoplastids
- New pradimicin derivatives for the treatment of diseases caused by kinetoplastids
- Phosphonate nucleosides useful in the treatment of viral diseases
- Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer
- Phosphonucleosides useful in the treatment of viral disorders
- Phosphonate nucleosides useful in the treatment of viral diseases
- Anti-cancer compounds
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY