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Organisation

Immunity and Inflammation Research Group

Division

Lifecycle:1 Jan 2019 →  Today
Organisation profile:

The main research topics include evaluation of leukocyte migration in inflammation and tumor biology with a main focus on chemokines. This includes biological and biochemical characterization of chemoattractants, their gene regulation and posttranslational processing, G protein-coupled receptor-mediated signal transduction, interactions with glycosaminoglycans and synergistic and antagonistic activities. The role of chemoattractants in (1) homeostatic and inflammatory leukocyte migration, (2) autoinflammation, autoimmunity and infection, (3) angiogenesis, (4) tumor development, (5) ischemia reperfusion injury, (6) allograft rejection and (7) fibrosis. They use mass spectrometry and protein sequencing (proteomics) for downstream processing of body fluids and chemical and recombinant protein production to determine the chemokine profile and activity in a wide range of animal models and diseases. A broad range of in vitro chemotaxis and signaling assays have been developed including the use of fluorescence and time-lapse video microscopy. In addition, they study the immunologic mechanisms underlying anti-tumor responses evoked by adoptive cell therapy following allogeneic bone marrow transplantation. Furthermore, the role of different immune regulatory cells (mesenchymal stem cells and myeloid suppressor cells) in immune events after transplantation is investigated.

Keywords:Immunology
Disciplines:Immunology