Modulation of molecular signaling to control the virulence of foodborne Clostridium perfringens

This project uses a cell-based system to investigate the host-pathogen interaction and quorum sensing (QS) systems' role in enterotoxin (CPE) production. To accomplish this project, strain selection, optimization of cell culture, host-pathogen interaction, and QS signalling system impact on CPE production are performed step by step. The last step is to determine the role of indole on cells exposed to cpe.

Keywords:virulence, toxin production, Control, Clostridium perfringens

Disciplines:Food microbiology