Researcher
Bart De Strooper
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- See also: Bart De Strooper (KU Leuven)
Affiliations
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - De Strooper Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 25
- Studying the role of microglia-specific endolysosomal dysfunction in ADFrom1 Oct 2023 → TodayFunding: Other international institutions, not mentioned elsewhere
- Analyzing the effect of complex genetic risk of Alzheimer’s disease on microglia responses in health and disease conditionsFrom1 Jun 2023 → TodayFunding: Other international institutions, not mentioned elsewhere
- Characterization of a novel knock-in Psen1 A431E (Jalisco) mouse modelFrom1 Mar 2023 → TodayFunding: Other international institutions, not mentioned elsewhere
- Uncovering microglial functions of BIN1 and PICALM in Alzheimer’s diseaseFrom1 Jan 2023 → TodayFunding: Private funding of national origin - undefined
- Antisense therapy for PSEN1 A431E Familial Alzheimer's diseaseFrom1 Jan 2023 → TodayFunding: Private funding of national origin - undefined
- Early microglia–neuron interactions in Alzheimer's DiseaseFrom1 Oct 2022 → TodayFunding: Other international institutions, not mentioned elsewhere
- Innovative in vivo screening method to cross the blood brain barrierFrom1 Mar 2022 → 29 Feb 2024Funding: Other international institutions, not mentioned elsewhere
- VIB Grant for De Strooper Lab_Period:2022-01-01-2026-12-31From1 Jan 2022 → TodayFunding: FRI - Project driven research
- Using Epigenetics to characterize the regulation of cellular states in microglia that contribute to Alzheimer’s disease pathologyFrom1 Nov 2020 → 31 Oct 2022Funding: Other international institutions, not mentioned elsewhere
- Resolving Alzheimer’s Disease: role of immunoresolving lipids in microgliaFrom1 Jul 2020 → 30 Jun 2023Funding: Other international institutions, not mentioned elsewhere
Publications
1 - 10 of 103
- Functional and topological analysis of PSENEN, the fourth subunit of the ?-secretase complex.(2024)
Authors: Lutgarde Serneels, Lucía Chávez Gutiérrez, Bart De Strooper
Pages: 105533 - New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of ?-secretases.(2024)
Authors: Bart De Strooper
Pages: 887-903 - Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-ß pathology.(2024)
Authors: Renzo Mancuso, Nicola Fattorelli, Anna Martinez Muriana, Emma Davis, Ivana Geric, Jessie Premereur, Paula Polanco Miquel, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, et al.
Pages: e-pub - Selective inhibitors of the PSEN1-gamma-secretase complex.(2023)
Authors: Lutgarde Serneels, Dries T'Syen, Bart De Strooper
Pages: 104794 - microRNA-132 regulates gene expression programs involved in microglial homeostasis.(2023)
Authors: Hannah Walgrave, Emma Davis, Susanne Rianneke Sierksma, Nicola Thrupp, Renzo Mancuso, Mark Fiers, Bart De Strooper, Evgenia Salta
Pages: 106829 - Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective ?-secretase inhibitors.(2023)
Authors: Lutgarde Serneels, Bart De Strooper
Pages: 115725 - MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease.(2023)
Authors: Sriram Balusu, Nicola Thrupp, Lutgarde Serneels, Dries T'Syen, Iordana Chrysidou, Amaia Arranz, Susanne Rianneke Sierksma, Wei-Ting Chen, Evgenia Salta, Mark Fiers, et al.
Pages: 1176-1182 - Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease.(2023)
Authors: Sara Calafate, Gökhan Özturan, Nicola Thrupp, Blanca Lorente Echeverria, Wei-Ting Chen, Mark Fiers, Bart De Strooper, Joris de Wit
Pages: 1021-1031 - Neurodegeneration cell per cell.(2023)
Authors: Sriram Balusu, Roman Praschberger, Bart De Strooper, Patrik Verstreken
Pages: 767-786 - The y-secretase substrate proteome and its role in cell signaling regulation.(2023)
Authors: Pengfei Hou, Magdalena Zielonka, Lutgarde Serneels, Anna Martinez Muriana, Nicola Fattorelli, Dries T'Syen, Sriram Balusu, Mark Fiers, Renzo Mancuso, Bart De Strooper
Pages: 4106-4122.e10
Patents
1 - 6 of 6
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)