Histone proteins are intimately associated with DNA to form the chromatin. Epigenetic posttranslational modifications (PTM) on histones regulate transcription in all Eukaryotes. Here, we will apply the latest in bottom-up mass spectrometry data independent acquisition (DIA) to simultaneously map hundreds of PTM combinations in a quantitative manner and to generate a first birdU+2019s eye view of the so-called histone code.
Date:1 Oct 2017 → 30 Sep 2021
Keywords:Epigenetics, Histones, Mass spectrometry
Disciplines:Bioinformatics and computational biology, Biomaterials engineering, Systems biology, Public health services, Other biological sciences, Scientific computing, Epigenetics, Medical biochemistry and metabolism, Biochemistry and metabolism, Pharmacotherapy, Biomarker discovery and evaluation, Other biotechnology, bio-engineering and biosystem engineering, Industrial biotechnology, Bio-informatics and computational biology not elsewhere classified, Other (bio)medical engineering, Drug discovery and development, Medicinal products, Pharmaceutics, Other pharmaceutical sciences, Other natural sciences, Toxicology and toxinology, Genetics, Public health care, Environmental engineering and biotechnology, Biomechanical engineering, Biological system engineering, Pharmacognosy and phytochemistry, Pharmacology