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Ion mobility assisted Data Independent Acquisition of the histone code: opening up peptide-centric data mining.
Histone proteins are intimately associated with DNA to form the chromatin. Epigenetic posttranslational modifications (PTM) on histones regulate transcription in all Eukaryotes. Here, we will apply the latest in bottom-up mass spectrometry data independent acquisition (DIA) to simultaneously map hundreds of PTM combinations in a quantitative manner and to generate a first birdU+2019s eye view of the so-called histone code.
Date:1 Oct 2017 → 30 Sep 2021
Keywords:Epigenetics, Histones, Mass spectrometry
Disciplines:Systems biology, Other biological sciences, Epigenetics, Medical biochemistry and metabolism, Biochemistry and metabolism, Pharmacotherapy, Biomarker discovery and evaluation, Bio-informatics and computational biology not elsewhere classified, Drug discovery and development, Medicinal products, Pharmaceutics, Other pharmaceutical sciences, Other natural sciences, Toxicology and toxinology, Genetics, Pharmacognosy and phytochemistry, Pharmacology