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Project
Randomized phase 2 trial of definitive radiotherapy with or without Formin in patients with inoperable stage 3 non-small cell lung cancer.
There is a presently unmet need for improvement of the outcome in patients with non-small cell lung cancer, who
present with locoregional extension, are not fit for concurrent chemoradiotherapy and are sequentially treated with
induction chemotherapy followed by definitive radiotherapy.
The present project aims at reducing their locoregional relapse rate. We hypothesize that the administration of oral
metformin during radiotherapy will decrease the hypoxic fraction of tumour cells which are then better targeted by
definitive radiation and become apoptotic. This will be evaluated using a randomised design where all patients will
receive definitive radiotherapy with or without metformin. In addition, the validated biomarker of tumour hypoxia 18FMISO
PET scintigraphy, and biomarkers of resistance, apoptosis and glucose metabolism will be evaluated for their
potential predictive value.
Date:1 Aug 2017 → 31 Jul 2021
Keywords:LUNG CANCER
Disciplines:Morphological sciences, Oncology