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Project
Specific nanobodies as a tool to study the role of gelsolin in tumor cell invasion, and to perturb its activity
We investigate the role of gelsolin, an actin binding protein, by using small antibodies (nanobodies) raised in llamas. The nanobodies are characterized biochemically, biophysically, and biologically and used in living (cancer) cells to modulate their behavior.
Date:1 Jan 2008 → 31 Dec 2010
Keywords:cytoskeleton, peptide aptamers, tumorigenesis
Disciplines:Oncology, Chemical product design and formulation, Medical biochemistry and metabolism, Morphological sciences, Catalysis and reacting systems engineering, Process engineering, Transport phenomena, Other (bio)chemical engineering, Biochemistry and metabolism, Separation and membrane technologies, General chemical and biochemical engineering, Systems biology