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Researcher
Jo Vandesompele
- Keywords:non-coding RNA, RNA, Applied bioinformatics, DNA, cancer, liquid biopsy, DNA and RNA sequencing, digital pcr
- Disciplines:Clinical genetics and molecular diagnostics, Single-cell data analysis, Cancer diagnosis, Cancer biology, Bioinformatics of disease, Bioinformatics data integration and network biology, Development of bioinformatics software, tools and databases, Cancer therapy, Bioinformatics and computational biology not elsewhere classified, Medical genomics, Medical epigenomics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 1997 → 30 Sep 2018
Projects
1 - 10 of 77
- Multiplex digital PCR to enable high-impact applications across diverse bioscience research groupsFrom1 Dec 2025 → TodayFunding: BOF - scientific equipment program
- Robust, sustainable and semi-automated sequencing library preparation through Mantis dispensing and PuriFY clean-upFrom1 Dec 2025 → TodayFunding: BOF - scientific equipment program
- Implementing cell-free RNA biomarkers for the minimally invasive diagnosis, risk stratification and follow-up of diffuse large B-cell lymphoma patientsFrom1 Feb 2025 → TodayFunding: Nonprofit institution or equivalents
- Cofunding core facility - The digital PCR CoreFrom1 Feb 2025 → TodayFunding: BOF - research organisations
- Studying cellular heterogeneity induced by targeted therapies in neuroblastoma using spatial transcriptomics and liquid biopsiesFrom1 Jan 2025 → TodayFunding: FWO research project (including WEAVE projects)
- Spatial mapping of mutant clones to understand the role of interclonal competition in human carcinogenesis.From1 Jan 2025 → TodayFunding: FWO research project (including WEAVE projects)
- Study of acquired resistance and recurrence through multi-omics spatial analysis of neuroblastomaFrom1 Jan 2025 → TodayFunding: Foundations, funds and other with scientific goal
- Mapping cellular heterogeneity induced by targeted therapies in neuroblastoma tumors using spatial transcriptomics and liquid biopsiesFrom25 Nov 2024 → TodayFunding: Nonprofit institution or equivalents
- Harnessing a xenograft rat model to illuminate tumor-derived extracellular RNA in liquid biopsiesFrom1 Nov 2024 → TodayFunding: FWO senior postdoctoral fellowship
- Photolithographic DNA printer for massively parallel synthesis of DNA oligonucleotides for spatial - omics and hybrid capture target enrichment applicationsFrom1 May 2024 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
1 - 10 of 435
- Human skeletal muscle fiber heterogeneity beyond myosin heavy chains(2025)Published in: NATURE COMMUNICATIONSISSN: 2041-1723Issue: 1Volume: 16
- Blood collection tube and RNA purification method recommendations for extracellular RNA transcriptome profiling(2025)Published in: NATURE COMMUNICATIONSISSN: 2041-1723Issue: 1Volume: 16
- Digital PCR-based gene expression analysis using a highly multiplexed assay with universal detection probes to study induced pluripotent stem cell differentiation into cranial neural crest cells(2025)Series: Methods in molecular biology (MIMB)Pages: 17 - 47
- Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk(2025)Published in: CELL METABOLISMISSN: 1932-7420Issue: 4Volume: 37Pages: 842 - 856.e7
- Characterizing the cell-free transcriptome in a humanized diffuse large B-cell lymphoma patient-derived tumor xenograft model for RNA-based liquid biopsy in a preclinical setting(2024)Published in: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESISSN: 1422-0067Issue: 18Volume: 25
- Transcriptomic signatures of human single skeletal muscle fibers in response to high-intensity interval exercise(2024)Published in: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGYISSN: 1522-1563Issue: 5Volume: 327Pages: C1249 - C1262
- Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic : role of the Belgian National Reference Centre(2024)Published in: VIROLOGY JOURNALISSN: 1743-422XIssue: 1Volume: 21
- Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data(2024)Published in: JOURNAL OF EXTRACELLULAR VESICLESISSN: 2001-3078Issue: 4Volume: 13
- HTSplotter : an end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening(2024)Published in: PLOS ONEISSN: 1932-6203Issue: 1Volume: 19
- Nucleic acid degradation as barrier to gene delivery : a guide to understand and overcome nuclease activity(2024)Published in: CHEMICAL SOCIETY REVIEWSISSN: 1460-4744Issue: 1Volume: 53Pages: 317 - 360
Patents
1 - 10 of 10
- Method to screen, diagnose or monitor treatment using increased numbers of deviating analytes
- Usages of recombinant extracellular vesicles
- Biomarkers for disease burden of neuroblastoma
- Inhibition of a lncRNA for treatment of melanoma
- Usages of recombinant extracellular vesicles
- Biomarkers for disease burden of neuroblastoma
- Usages of recombinant extracellular vesicles
- Inhibition of a lncRNA for treatment of melanoma
- NEUROBLASTOMA PROGNOSTIC MULTIGENE EXPRESSION SIGNATURE
- Inhibition of a lncRNA for treatment of melanoma
Linked dataset
1 - 7 of 7
- Characterizing the cell-free transcriptome in a humanized DLBCL patient-derived tumor xenograft model for RNA-based liquid biopsy in a preclinical setting
- Benchmarking blood collection tubes and processing intervals for extracellular vesicle performance metrics
- Blood plasma and FFPE derived total RNA seq dataset from DLBCL and PMBCL patients
- Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA
- mRNA Capture Sequencing and RT-qPCR for the Detection of Pathognomonic, Novel, and Secondary Fusion Transcripts in FFPE Tissue: A Sarcoma Showcase
- Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma
- Messenger RNA capture sequencing of extracellular RNA from human biofluids using a comprehensive set of spike-in controls