Researcher
Karolien De Bosscher
- Keywords (Ghent University):cellular signal transduction, nuclear receptors
- Disciplines (Flanders Institute for Biotechnology):Analytical biochemistry, Cell death and senescence, Analysis of next-generation sequence data, General diagnostics
- Disciplines (Ghent University):Nucleic acids, Other organic elements and compounds, Proteins, Regulation of metabolism, Cell signalling, Transcription and translation, Endocrinology and metabolic diseases not elsewhere classified, Cell death, Cancer biology, Medical biochemistry and metabolism not elsewhere classified, Animal cell and molecular biology, Carbohydrates, Energy metabolism, Inorganic elements and compounds, Lipids
Affiliations
- De Bosscher Lab (Research group)
Responsible
From1 Jan 2019 → Today - Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Tavernier Lab (Research group)
Member
From1 Jan 2017 → 31 Dec 2018 - Department of Biochemistry (Department)
Member
From7 Oct 2010 → 30 Sep 2018 - Department of Physiology (Department)
Member
From1 Jan 2009 → 6 Oct 2010 - Department of Biomedical molecular biology (Department)
Member
From1 Oct 1995 → 31 Dec 2008
Projects
1 - 10 of 20
- Disentangling the complexity and diversity of glucocorticoid receptor signalingFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Development of hybrid molecules targeting glucocorticoid and peroxisome proliferator-activated receptor-based heterodimers to combat inflammationFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- In-depth study of structure/activity relations of the glucocorticoid receptor and its ligands via an extreme mutation scanFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- Study of novel bivalent ligands targeting glucocorticoid and mineralocorticoid receptor heterodimers: towards an improved glucocorticoid-based multiple myeloma therapy"From1 Nov 2023 → TodayFunding: Nonprofit institution or equivalents
- Integrative interactome and protein modification analysis of HNF4α in sepsisFrom1 Nov 2023 → TodayFunding: FWO fellowships
- Development of steroid-based GR-PPARα conjugates for the treatment of chronic inflammatory diseasesFrom1 Oct 2023 → TodayFunding: BOF - projects
- The Best Of Both Worlds: Nuclear Receptor Heterodimers To Battle Against Rheumatoid Arthritis.From1 Oct 2022 → 31 Dec 2023Funding: FWO junior postdoctoral fellowship
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomicsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- STOP_SEPSIS: investigation into a new concept of sepsis, the greatest unmet medical need of our times.From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
Publications
1 - 10 of 36
- The zinc-binding group effect : lessons from non-hydroxamic acid vorinostat analogs(2023)
Authors: Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D'hooghe
Pages: 7698 - 7729 - The biologist’s guide to the glucocorticoid receptor’s structure(2023)
Authors: Nick Deploey, Laura Van Moortel, Inez Rogatsky, Frank Peelman, Karolien De Bosscher
- Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding(2022)
Authors: Steven Timmermans, Nicolette J.D. Verhoog, Kelly Van Looveren, Sylviane Dewaele, Tino Hochepied, Melanie Eggermont, Barbara Gilbert, Anne Boerema-de Munck, Tineke Vanderhaeghen, Joke Vanden Berghe, et al.
- Hepatic glucocorticoid‐induced transcriptional regulation is androgen‐dependent after chronic but not acute glucocorticoid exposure(2022)
Authors: Jacobus C. Buurstede, Susana N. Paul, Karolien De Bosscher, Onno C. Meijer, Jan Kroon
- The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma(2022)
Authors: Silke Geurs, Dorien Clarisse, Eleni Staessens, Karolien De Bosscher, Matthias D'hooghe
Number of pages: 1 - Regulatory role of the intestinal microbiota in the immune response against Giardia(2021)
Authors: Brecht Maertens, Aurélie Gagnaire, Oonagh Paerewijck, Karolien De Bosscher, Peter Geldhof
- Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium(2020)
Authors: Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, et al.
- Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system(2020)
Authors: Kelly Van Looveren, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Marlies Ballegeer, Jolien Souffriau, Melanie Eggermont, Jolien Vandewalle, Lise Van Wyngene, Karolien De Bosscher, et al.
- Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies(2020)
Authors: Dorien Clarisse, Fritz Offner, Karolien De Bosscher
- TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile(2019)
Authors: Karen Dendoncker, Steven Timmermans, Jolien Vandewalle, Melanie Eggermont, Joanna Lempiäinen, Ville Paakinaho, Evelien Van Hamme, Sylviane Dewaele, Sofie Vandevyver, Marlies Ballegeer, et al.
Pages: 12942 - 12951