Researcher
Pieter Leyssen
- Disciplines:Bacteriology, Infectious diseases, Virology
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 10
- Integrated Services for Infectious Disease Outbreak ResearchFrom1 Feb 2022 → TodayFunding: Horizon Europe - Research Infrastructures
- COVID19:HTS-kernFrom25 Mar 2020 → 30 Jun 2022Funding: Foreign private sponsor - undefined
- Mapping the druggable genome/anti-virome of neglected & emerging RNA viruses using a strategy based on multicolor/multiplex high-content imaging, in vitro evolution and chemogenomicsFrom1 Mar 2020 → 28 Feb 2021Funding: BOF - postdoctoral mandates
- Advancing European Research Infrastcuture on Highly Pathogenic AgentsFrom1 Jan 2019 → 30 Jun 2022Funding: H2020 - Research Infrastructures
- IPSC-HEPs: hepatotoxicity and drug metabolism by biotech and pharmaceutical companies.From1 Oct 2017 → 30 Sep 2019Funding: IOF - Industrial Research Fund
- Valorization of novel strategies for the prevention of viral infection and inhibition of viral replication.From1 Nov 2015 → TodayFunding: IOF - Industrial Research Fund, IOF - mandates
- Development and application of new techniques to investigate the initial steps of the infection process.From1 Jan 2015 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Crimean Congo Hemorrhagic Fever. Modern approaches to diagnostics, epidemiology, prevention, therapy and preparedness.From1 Oct 2010 → 31 Mar 2015Funding: General Activities (Annex IV)
- Biodiversity and emerging viruses in the Indian Ocean: selection of natural drug candidates to fight the Chikungunya virus.From14 Nov 2008 → 13 Nov 2010Funding: Other European institutions (outside EU)
- Novel strategies against infectious diseasesFrom1 Nov 2005 → TodayFunding: IOF - Industrial Research Fund, IOF - mandates
Publications
1 - 10 of 172
- Multiplexed multicolor antiviral assay amenable for high-throughput research(2024)
Authors: Li-Hsin Li, Yun-An Huang, Madina Rasulova, Hendrik Jan Thibaut, Sebastiaan ter Horst, Joana Duarte Da Rocha Pereira, Suzanne Kaptein, Pieter Leyssen, Johan Neyts, Kai Dallmeier
- Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects(2023)
Authors: Dirk Jochmans, Johan Neyts, Steven De Jonghe, Pieter Leyssen
- Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2(2023)
Authors: Steven De Jonghe, Pieter Leyssen, Johan Neyts, Ellen Van Damme
- Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery(2023)
Authors: Kayvan Abbasi, Dirk Jochmans, Steven De Jonghe, Hendrik Jan Thibaut, Johan Neyts, Manon Laporte, Pieter Leyssen
- Bis(Benzofuran-1,3-N,N-heterocycle)s as Symmetric and Synthetic Drug Leads against Yellow Fever Virus(2022)
Authors: Pieter Leyssen, Johan Neyts
- Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys(2022)
Authors: Rana Abdelnabi, Johan Neyts, Pieter Leyssen
Pages: 1376 - + - Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort(2022)
Authors: Dirk Jochmans, Steven De Jonghe, Kayvan Abbasi, Johan Neyts, Pieter Leyssen
- Computer-Aided Design and Synthesis of (Functionalized quinazoline)-(α-substituted coumarin)-arylsulfonate Conjugates against Chikungunya Virus(2022)
Authors: Pieter Leyssen, Johan Neyts
- Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: Evaluation of 5676 Phase 1 Passed Structures(2022)
Authors: Dirk Jochmans, Steven De Jonghe, Pieter Leyssen, Johan Neyts
Pages: 3101 - 3111 - HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect(2022)
Authors: Rana Abdelnabi, Suzanne Kaptein, Sebastiaan ter Horst, Leen Delang, Joana Duarte Da Rocha Pereira, Lotte Coelmont, Pieter Leyssen, Kai Dallmeier, Valentijn Vergote, Elisabeth Heylen, et al.
Patents
1 - 7 of 7
- Compounds for the treatment of covid-19 (Inventor)
- Compounds for the treatment of covid-19 (Inventor)
- Antiviral compounds (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral activity of novel bicyclic heterocycles (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)