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Researcher
Steven Van Cruchten
- Research Expertise:xxxxxxx
- Keywords:TOXICOLOGY, IN VITRO TESTS, EMBRYOTOXICITY, ANIMAL MODELS, Veterinary medicine
- Disciplines:Biomarker discovery, In vitro testing, Non-clinical studies, Veterinary medicine, Other veterinary sciences
- Research techniques:-omics, ELISA, immunohistochemistry, spectrophotometry, luminiscence, LC-MS
- Users of research expertise:CROs; chemical, pharma and biotech companies
Affiliations
- Comparative Perinatal Development (CoPeD) (Research group)
Responsible
From1 Sep 2024 → Today - Comparative Perinatal Development (CoPeD) (Research group)
Member
From1 Feb 2010 → 31 Aug 2024
Projects
1 - 10 of 19
- Functional Anatomy using Classical and Cutting-Edge Techniques (FAC²ET).From1 Jan 2025 → TodayFunding: FWO scientific research network
- Reducing Non-Human Primates in Non-Clinical Assessment: The European Initiative on Minipig and Micropig Models (NHPig).From1 Oct 2024 → TodayFunding: HORIZON.2.1 - Health
- Advancing the Zebrafish Embryo Developmental Toxicity Assay (ZEDTA) towards a sensitive screening assay.From1 Nov 2020 → 31 Oct 2023Funding: BOF - doctoral mandates
- Qualification of the juvenile minipig for pediatric safety testing of single stranded oligonucleotides (SSOs).From15 Jul 2020 → 14 Jul 2021Funding: BOF - doctoral mandates
- I-PREDICT: Innovative Physiology-based pharmacokinetic model to pREdict Drug exposure In neonates undergoing Cooling Therapy.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Advancing the zebrafish embryo developmental toxicity assay from screening to regulatory testing.From1 Nov 2019 → 31 Oct 2020Funding: BOF - doctoral mandates
- Assessment of skeletal endpoints and exposure in an extended Zebrafish Developmental Toxicity Assay (ZEDTA) using mammalian teratogens.From10 Apr 2018 → 9 Apr 2020Funding: Foreign public sponsor
- Bioactivation of human proteratogens in the zebrafish embryo model, a potential alternative test for development toxicity assessment.From1 Jan 2018 → 31 Dec 2021Funding: FWO Strategic Basic Research Grant
- Reaction phenotyping and CRISPR/Cas9 genome editing of xenobiotic CYP isoenzymes in the zebrafish embryo: effects on bioactivation of prodrugs and normal functioning.From1 Oct 2016 → 31 Dec 2017Funding: Fund Recuperation Fiscal Exemption
- Construction and activity of recombinant cythochrome P450 enzymes as an in vitro system for reaction-phenotyping of drug candidates in the Göttingen minipig.From18 Jul 2016 → 31 Dec 2017Funding: Foreign foundations, funds with scientific view
Publications
31 - 40 of 102
- Sterile pericarditis in Aachener minipigs as a model for atrial myopathy and atrial fibrillation(2021)Published in: Journal of visualized experimentsISSN: 1940-087XVolume: 99Pages: 1 - 14
- Preterm birth affects early motor development in pigs(2021)Published in: Frontiers in PediatricsISSN: 2296-2360Volume: 9
- Handling associated with drenching does not impact survival and general health of low birth weight piglets(2021)Published in: AnimalsISSN: 2076-2615Volume: 11
- Hepatic cytochrome P450 abundance and activity in the developing and adult Gottingen Minipig: pivotal data for PBPK modeling(2021)Published in: Frontiers in pharmacologyISSN: 1663-9812Volume: 12
- Low birth weight female piglets show altered intestinal development, gene expression, and epigenetic changes at key developmental loci(2021)Published in: The FASEB journalISSN: 0892-6638Volume: 35
- The neonatal and juvenile pig in pediatric drug discovery and development(2020)Published in: PharmaceuticsISSN: 1999-4923Volume: 13
- A physiology-based pharmacokinetic framework to support drug development and dose precision during therapeutic hypothermia in neonates(2020)Published in: Frontiers in pharmacologyISSN: 1663-9812Volume: 11
- Use of zebrafish in drug discovery toxicology(2020)Published in: Chemical research in toxicologyISSN: 0893-228XVolume: 33Pages: 95 - 118
- Birthweight determines intestinal microvasculature development and alters endothelial nitric oxide synthase density in young piglets(2020)Published in: Anatomia, histologia, embryologia : journal of veterinary medicine: series CISSN: 0340-2096Volume: 99
- A medium-throughput system for in vitro oxidative stress assessment in IPEC-J2 cells(2020)Published in: International journal of molecular sciencesVolume: 21