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Stem4Biodiversity, the generation and banking at room temperature of primordial germ cell-like cells from induced pluripotent stem cells to improve biodiversity conservation. (Stem4Biodiversity) University of Antwerp

Ruth Appeltant
Catholic University of Louvain, Veterinary physiology and biochemistry
The earth faces unprecedented extinction levels, termed "the sixth extinction". Assisted reproductive technology and cryobanking emerged as pivotal strategies in safeguarding the genetic diversity in mammalian species. However, oocyte scarcity, harvesting and cryopreservation challenges persist due to the absence of species-specific protocols. Moreover, cryobanks require substantial investment and logistical support, making them available in ...

Fiction Film and Borderlands (EU637) Vrije Universiteit Brussel

Kevin Smets
FORMER_ECHO: Research group on media, culture and politics, Brussels Interdisciplinary Research centre on Migration and Minorities, ECHO: Media, Culture & Politics Research Group, Communication Sciences
REEL BORDERS aims to bring fiction film to the centre of discussions about borders and belonging. As different institutions and actors increasingly turn to fiction film to circulate messages about borders, the study looks at how borders and fiction film have been related since the early 20th century. Border regimes are intimately intertwined with cultural imaginations and representations of borders and their insiders and outsiders.
This ...

Strengthening Climate Change Resilience among Communities and Ecosystems in the Lake Victoria Basin. University of Antwerp

Steven Van Passel
Jaramogi Oginga Odinga University of Science and Technology, Engineering Management
The Lake Victoria Basin (LVB) is highly vulnerable to climate change and climate variability and is already experiencing increased intensities and frequencies of severe, climate change-related weather events, causing significant interruptions of economic activities, destruction and losses. Climate change is also expected to increase the rate of environmental degradation, spread of disease vectors, increase the frequency and severity of floods ...

Study of human lymphoid cell differentiation using gene-modified embryonic stem cells and induced pluripotent stem cells from immunodeficiency patients Ghent University

Bart Vandekerckhove, Jean Plum
Department of Clinical chemistry, microbiology and immunology

Pluripotent stem cells will be generated from patients with an inborn immune (T/NK) deficiency. In addition, gene modified human embryonic stem cells will be generated for lineage tracing and deletion mutants. Using these cell lines T and NK differentiation will be studied and the effect of the targeted genes on differentiation will be analyzed.

Ceation of patient specific stem cells through somatic cell nuclear transfer of induced pluripotent stem cells Ghent University

Petra De Sutter
Department of Pharmaceutics, Department of Uro-gynaecology

Somatic cell nuclear transfer and parthenogenesis involve two major strategies to produce patient specific pluripotent stem cells. The key steps in this technology (enucleation artificial activation) need further optimisation in human. In parallel, we will ivestigate whether induced pluripotent stem cells have similar characteristics and capacities as human embryonic stem cells by intensive molecular comparsion.

Mechanisms affecting the homing, engraftment and functioning of hematopoietic stem cells in a compromised bone marrow environment: relevance to treatment of the elderly cancer patient by stem cell therapy KU Leuven

Christa Maes
Skeletal Biology and Engineering Research Center

Most people diagnosed with cancer, including a variety of life-threatening hematologic malignancies, are over 65 years old. The options and outcomes of treating the elderly cancer patient with hematopoietic stem cell (HSC) therapy are limited. Achieving better long-term engraftment following transplantation in this growing target group will rely on profound knowledge of the interactions between HSCs and the bone marrow (BM) environment, ...

iSTEM, a support cell for schools in STEM didactics (iSTEM). University of Antwerp

Peter Van Petegem
Katholieke Universiteit Leuven, Hasselt University, Arteveldehogeschool, Hogeschool PXL, Vrije Universiteit Brussel, EduBROn
The five pillars for iSTEM didactics are: • interdisciplinary integration of STEM content • problem-centered learning • learning and designing • cooperative learning • subject didactics basis Teacher Design Teams (TDT) or Learning Design Studios will be used as an approach to foster professional learning of teachers and to introduce the teachers in this approach. The aim of the TDT's is to develop materials and methods which will be implemented ...

Generation of autologous T cells against acute myeloid leukemia by transduction of hematopoietic stem cells with T cell receptor genes and subsequent differentiation to T cells Ghent University

Bart Vandekerckhove
Department of Clinical chemistry, microbiology and immunology

Hematopoietic stem cells will be transduced to express a T Cell Receptor. This receptor will be optained by immunizing against WT1 tumor antigen. The T cell receptor genes will be cloned from WT1 speciific T cells and subsequently used for transduction of the stem cells. Stem cells will be differentiated in vitro to T cells and functionality will be assayed in an in vivo animal model

Generation of autologous T cells against acute myeloid leukemia by transduction of hematopoietic stem cells with T cell receptor genes and subsequent differentiation to T cells Ghent University

Bart Vandekerckhove
Department of Clinical chemistry, microbiology and immunology

Hematopoietic stem cells will be transduced to express a T Cell Receptor. This receptor will be optained by immunizing against WT1 tumor antigen. The T cell receptor genes will be cloned from WT1 speciific T cells and subsequently used for transduction of the stem cells. Stem cells will be differentiated in vitro to T cells and functionality will be assayed in an in vivo animal model

Human Stem Cell Derived Liver Cells for Disease Modeling and Whole Organ Engineering KU Leuven

Catherine Verfaillie
Oral and Maxillo-facial Surgery - Imaging & Pathology (OMFS-IMPATH), Stem Cell and Developmental Biology

The vital blood system in mammals is continuously regenerated throughout life by a process called hematopoiesis. In hematopoiesis, a stem cell population called hematopoietic stem cells (HSC’s) undergo differentiation and produce specialized mature blood cells including red blood cells, megakaryocytes and myeloid cells. Even a small failure in this process can result in hematological disorders such as anemia and leukemia. ...