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Monoaminergic and neuroinflammatory markers in dementia with Lewy bodies to improve differential dementia diagnosis. University of Antwerp

Peter De Deyn
Experimental Neurobiology Unit (ENU), Flemish Institute for Technological Research, Neurochemistry and behaviour
Due to overlapping clinical and pathological features, the differential diagnosis between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) becomes extremely difficult. Besides, there still is no approved treatment for DLB. The current application, therefore, aims at identifying neurochemical markers in blood (serum) and cerebrospinal fluid (CSF) to improve the diagnostic accuracy among these syndromes. Based on our previous data, ...

Biomarkers for differential dementia diagnosis. University of Antwerp

Sebastiaan Engelborghs
Neurochemistry and behaviour
The CSF biomarkers Ab1-42, T-tau and P-tau181P have been developed to allow (early) dementia diagnosis. The contribution of biomarkers to the differential diagnosis between Alzheimer's disease (AD) and non-AD dementias is clinically very relevant but remains poorly studied. The primary aim of the research project that is described in this grant application is to validate the role of the above-mentioned CSF biomarkers for differential AD versus ...

Alzheimer disease cerebrospinal fluid biomarkers for differential dementia diagnosis: limitations and opportunities. University of Antwerp

Maria Bjerke
Neurochemistry and behaviour
The project aims to improve the differential dementia diagnosis using cerebrospinal fluid (CSF) biomarkers by increasing our insight in the overlap of the existing core AD CSF biomarkers between AD and non-AD dementias. Considering the large inter-individual variability in Aβ load, normalizing CSF Aβ1-42 to the most abundant and stably produced Aβ isoform, i.e. Aβ1-40, may enable the diagnosis of high Aβ-producing AD patients ('false negatives') ...

Biochemical markers for improved diagnostic discrimination of Alzheimer's disease from dementia with Lewy bodies. University of Antwerp

Sebastiaan Engelborghs
Neurochemistry and behaviour
This project aims to investigate biochemical markers for dementia with Lewy bodies aiming at improved clinical diagnosis of this neurological disorder that is often misdiagnosed as Alzheimer's disease. This research project aims at improving the AD versus DLB differential dementia diagnosis, combining both existing and new biomarkers:Neurodegenerative dementias are characterized by changes in the brain that include aggregation and deposition of ...

Changing gaze, changing perception: How participatory performative and visual art-practices can empower people with dementia and their caregivers to cope with the condition KU Leuven

Niels Hendriks, Kristof Vrancken
Inter-Actions Research Unit, Genk Campus, Media Culture & Policy Lab, Media, Information & Persuasion Lab, Contextualized Creation, Genk

Although dementia is increasingly easy to diagnose, it currently remains a progressive, incurable condition. People with dementia and their social circles have to deal not only with this fatal fact, but also with the taboo surrounding it. The stigmatizing ways in which people with dementia, their loved ones and the broader society perceive dementia are not beneficial to the course of the disease: they even contribute ...

Changing gaze, changing perception: How participatory performative and visual art-practices can empower people with dementia and their caregivers to cope with the condition LUCA School of Arts

Kristof Vrancken
KU Leuven, LUCA School of Arts, Future Scenarios (Genk)

Although dementia is increasingly easy to diagnose, it currently remains a progressive, incurable condition. People with dementia and their social circles have to deal not only with this fatal fact, but also with the taboo surrounding it. The stigmatizing ways in which people with dementia, their loved ones and the broader society perceive dementia are not beneficial to the course of the disease: they even contribute to a worsening of the ...

Changing gaze, changing perception: How participatory performative and visual art-practices can empower people with dementia and their caregivers to cope with the condition LUCA School of Arts

Kristof Vrancken
Future Scenarios (Genk), KU Leuven
Although dementia is increasingly easy to diagnose, it currently remains a progressive, incurable condition. People with dementia and their social circles have to deal not only with this fatal fact, but also with the taboo surrounding it. The stigmatizing ways in which people with dementia, their loved ones and the broader society perceive dementia are not beneficial to the course of the disease: they even contribute to a worsening of the ...

Memorandum:Discourse-analytical research of dementia communication KU Leuven

Priscilla Heynderickx
Multimodality, Interaction and Discourse, Antwerp Campuses, Linguistics Research Unit, Antwerp Campuses

According to Alzheimer’s disease International there were almost 47 million people with dementia worldwide in 2015. This number will substantially increase in the coming decades. Additionally, the number of people dealing with the disease (such as relatives and caregivers) is three times as high as the number of people with dementia. The stigma around dementia has a negative impact on almost all medical challenges, such as a ...

MemorandumDiscourse-analytical research concerning dementia (patients) KU Leuven

Priscilla Heynderickx
Multimodality, Interaction and Discourse, Antwerp Campuses
According to Alzheimer’s disease International there were almost 47 million people with dementia worldwide in 2015. This number will substantially increase in the coming decades. Additionally, the number of people dealing with the disease (such as relatives and caregivers) is three times as high as the number of people with dementia. The stigma around dementia has a negative impact on almost all medical challenges, such as a timely ...

Characterization and validation of biological markers of dementia and mild cognitive impairment University of Antwerp

Neurochemistry and behaviour
Mild cognitive impairment (MCI) is a clinical heterogeneous syndrome that is characterised by memory problems or other cognitive complaints that are not severe enough to fulfil the diagnostic criteria of dementia. The diagnosis of MCI refers to a state intermediate between normal ageing and dementia. Yearly, approximately 12% of the MCI patients convert to dementia, mostly AD, although a number of MCI patients remain stable or even improve and ...