Synthesis and evaluation of microcin C analogs as aminoacyl-tRNA synthetase inhibitors. KU Leuven
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In our laboratory for organic synthesis in Leuven, a lot of synthetic methods have been developed concerning organic polycyclic donor systems such as pentacene, carbazoles and more recently indolo[3,2-b]carbazoles (ICZs). This project is related to the ICZs and will focus on developing new synthetic methodologies to prepare novel building blocks, which will be coupled with known acceptor moieties like diketopyrrolopyrrole (DPP), ...
Chronic lung allograft dysfunction (CLAD) continues to limit long-term survival after lung transplantation (LTx) since three decades. With the recent phenotyping of CLAD into an obstructive and restrictive clinical entity, called bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS) respectively, additional questions have emerged concerning underlying mechanisms and specific characteristics between BOS and RAS. ...
The introduction of biologics has heralded a new era for treatment of immune-mediated inflammatory diseases (IMIDs), including ankylosing spondylitis (AS), psoriasis and inflammatory bowel diseases (IBD). Although these agents show efficacy in many patients, a substantial proportion of patients fails to respond, loses response over time or develops potentially therapy-limiting adverse events. One possible mechanism explaining the failure of ...
Chronic arthritides are hardly studied in central Africa. Our recent studies in Rheumatoid arthritis in the DR Congo showed different demographic and phenotypic characheristics compared to a Caucasian population. Data in the field of Spondyloarthritis (SpA) are scarses. The current project aims to study the epidemiology, clinical diagnosis including immunogenetic phenotype and management of SpA in Kinshasa, DR Congo. It will be based on four ...
Parents of children and adolescents with autism spectrum disorder (ASD) face specific challenges in parenting. However, little is known about parenting behaviours among parents of a child with ASD. Moreover, the literature is especially limited regarding adolescence (12 – 16 years), although this period is associated with additional challenges in parenting, given the multiple physical, social and psychological changes that characterize ...