Projects
Analysis of shape-function relations in complex muscular-sceletal systems using computer modeling and measurement of mechanical stress and strain distributions. University of Antwerp
Analysis of shape-function relations in complex muscular-sceletal systems using computer modeling and measurement of mechanical stress and strain distributions. University of Antwerp
Noninvasive 3D endoscopy and finite-element modeling for objective diagnosis and reconstruction of pathological middle ears. University of Antwerp
Statistical modeling of image processing methods in medical imaging Ghent University
Biomechanics of brain contusions: an injury criterion for developing safer headgear. KU Leuven
Traumatic brain injury (TBI) is a global health concern and a major cause of mortality and lifelong disability, affecting millions of people of all ages yearly. Victims of bicycle accidents are particularly prone to focal and diffuse TBI, with cerebral contusion being one of the most frequently observed focal injuries. Since reversing the outcome of TBI is, as of yet, therapeutically impossible, research on prevention and protection ...
Arterial biomechanics in 4D: understanding the long-term effects of mechanical overload KU Leuven
Various surgical interventions, such as vascular clamping, balloon angioplasty, or stenting, induce mechanical overload to arterial tissue, often leading to tissue damage. This overloading and resulting damage triggers growth and remodeling processes in the tissue, causing changes in mass and microstructure. This can lead to healing of the tissue, but the remodeling processes can also cause maladaptation. It remains unclear what triggers ...
Development, validation and application of a novel foot-ankle model to evaluate ligament behaviour in patients with ankle instability KU Leuven
Ankle sprain is one of the most common musculoskeletal injuries, often resulting in lateral ankle ligament tears or ruptures. Thirty to fifty percent of the patients develop chronic ankle instability (CAI) after a first ankle sprain, including persistent complaints of pain, swelling and/or the feeling of giving way in combination with recurrent sprains. CAI may be caused by mechanical (MAI) or functional ankle instability (FAI) or a ...
Modelling of gene networks for steering of biomimetic production processes in tissue engineering. KU Leuven
The specialization of cartilage cells, or chondrogenic differentiation, is an intricate and meticulously regulated process that plays a vital role in both bone formation and cartilage regeneration. This PhD work centers on the development of computational models to study the molecular regulation of this process. First, we investigate how individual genes and their defects contribute to the overall change in functionality of the growth plate, ...
Predictive simulations to explore gait control in children with cerebral palsy and provide guidance in the clinical decision making process. KU Leuven
Physics-based simulations of human movement have the potential to predict the functional outcome of treatments, thereby allowing clinicians to personalize and optimize clinical decision-making. These predictive simulations would be particularly valuable for treatments with modest and unpredictable outcomes, such as orthopedic surgeries aiming to improve walking abilities of children with cerebral palsy (CP). Yet computational and modeling ...